Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice
Cadmium-based quantum dots (QDs) have been extensively used for biomedical applications for the last decade. They have also been researched for drug and gene delivery. For this reason, efforts have been placed on evaluating their toxicity at in vivo level. The most widely used quantum dots are CdSe...
| Những tác giả chính: | , , , , , , , , , , |
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| Định dạng: | Journal Article |
| Ngôn ngữ: | English |
| Được phát hành: |
2013
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| Truy cập trực tuyến: | https://hdl.handle.net/10356/97740 http://hdl.handle.net/10220/17842 |
| _version_ | 1826111490823815168 |
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| author | Yong, Ken-Tye Liu, Jing Law, Wing-Cheung Liu, Jianwei Hu, Rui Liu, Liwei Zhu, Jing Chen, Hongyan Wang, Jianhua Hu, Yazhuo Ye, Ling |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Yong, Ken-Tye Liu, Jing Law, Wing-Cheung Liu, Jianwei Hu, Rui Liu, Liwei Zhu, Jing Chen, Hongyan Wang, Jianhua Hu, Yazhuo Ye, Ling |
| author_sort | Yong, Ken-Tye |
| collection | NTU |
| description | Cadmium-based quantum dots (QDs) have been extensively used for biomedical applications for the last decade. They have also been researched for drug and gene delivery. For this reason, efforts have been placed on evaluating their toxicity at in vivo level. The most widely used quantum dots are CdSe QDs and thus it is important for one to investigate the potential toxicity in vivo. In this contribution, we systematically study the effect of phospholipid micelle-encapsulated CdSe/CdS/ZnS QDs on the long term in vivo toxicity in Kunming mice. The biodistribution, animal survival, animal weight, hematology, blood biochemistry, and organ histology and their respective fluorescent images were determined at an overdose (50 mg kg−1) of phospholipid micelle-encapsulated QDs over 112 days (16 weeks) period. The results show that the phospholipid micelle-encapsulated QDs formulation did not result in noticeable toxicity. Serum analysis has shown no changes in the treated mice when compared to mice treated with PBS buffer solution. Histological analysis of tissues from major organs indicated that there are no acute toxic effects of the QDs in vivo. Fluorescent images indicated that the majority of the QDs accumulated in the liver and spleen. Due to the widespread use of Cd-based QDs and the potential for clinical use, these results are necessary and confirm the minimal health risk to use QDs as optical contrast agents and therapeutic carriers. |
| first_indexed | 2024-10-01T02:51:35Z |
| format | Journal Article |
| id | ntu-10356/97740 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:51:35Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/977402020-03-07T14:02:35Z Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice Yong, Ken-Tye Liu, Jing Law, Wing-Cheung Liu, Jianwei Hu, Rui Liu, Liwei Zhu, Jing Chen, Hongyan Wang, Jianhua Hu, Yazhuo Ye, Ling School of Electrical and Electronic Engineering Cadmium-based quantum dots (QDs) have been extensively used for biomedical applications for the last decade. They have also been researched for drug and gene delivery. For this reason, efforts have been placed on evaluating their toxicity at in vivo level. The most widely used quantum dots are CdSe QDs and thus it is important for one to investigate the potential toxicity in vivo. In this contribution, we systematically study the effect of phospholipid micelle-encapsulated CdSe/CdS/ZnS QDs on the long term in vivo toxicity in Kunming mice. The biodistribution, animal survival, animal weight, hematology, blood biochemistry, and organ histology and their respective fluorescent images were determined at an overdose (50 mg kg−1) of phospholipid micelle-encapsulated QDs over 112 days (16 weeks) period. The results show that the phospholipid micelle-encapsulated QDs formulation did not result in noticeable toxicity. Serum analysis has shown no changes in the treated mice when compared to mice treated with PBS buffer solution. Histological analysis of tissues from major organs indicated that there are no acute toxic effects of the QDs in vivo. Fluorescent images indicated that the majority of the QDs accumulated in the liver and spleen. Due to the widespread use of Cd-based QDs and the potential for clinical use, these results are necessary and confirm the minimal health risk to use QDs as optical contrast agents and therapeutic carriers. 2013-11-25T07:48:56Z 2019-12-06T19:46:01Z 2013-11-25T07:48:56Z 2019-12-06T19:46:01Z 2013 2013 Journal Article Liu, J., Law, W.-C., Liu, J., Hu, R., Liu, L., Zhu, J., et al. (2013). Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice. RSC Advances, 3(6), 1768-. 2046-2069 https://hdl.handle.net/10356/97740 http://hdl.handle.net/10220/17842 10.1039/c2ra21990e en RSC advances |
| spellingShingle | Yong, Ken-Tye Liu, Jing Law, Wing-Cheung Liu, Jianwei Hu, Rui Liu, Liwei Zhu, Jing Chen, Hongyan Wang, Jianhua Hu, Yazhuo Ye, Ling Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice |
| title | Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice |
| title_full | Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice |
| title_fullStr | Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice |
| title_full_unstemmed | Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice |
| title_short | Toxicity assessment of phospholipid micelle-encapsulated cadmium-based quantum dots using Kunming mice |
| title_sort | toxicity assessment of phospholipid micelle encapsulated cadmium based quantum dots using kunming mice |
| url | https://hdl.handle.net/10356/97740 http://hdl.handle.net/10220/17842 |
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