Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection
In this study, we performed finite element method (FEM) simulations to optimize the configuration of gold nanorods (GNR) enhanced surface plasmon resonance (SPR) sensor and discovered its application for multiplex antigens detection. Our work analyzed the near-field coupling between the sensing film...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/97756 http://hdl.handle.net/10220/12169 |
| _version_ | 1811687360998408192 |
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| author | Dinish, U. S. Gong, Tianxun Zeng, Shuwen Olivo, Malini Yong, Ken-Tye |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Dinish, U. S. Gong, Tianxun Zeng, Shuwen Olivo, Malini Yong, Ken-Tye |
| author_sort | Dinish, U. S. |
| collection | NTU |
| description | In this study, we performed finite element method (FEM) simulations to optimize the configuration of gold nanorods (GNR) enhanced surface plasmon resonance (SPR) sensor and discovered its application for multiplex antigens detection. Our work analyzed the near-field coupling between the sensing film and GNR. By systematically study the effect of gold film thickness, GNR-to-film distance and GNR dimensions on SPR, it was found that for GNR width smaller than 40nm, length change in GNR brought about significant SPR wavelength shift on the sensor, while the sensor is insensitive for GNR-to-film distance. As an application, we adopted GNRs of width 20 nm and aspect ratios from 2 to 4 and demonstrated the concept of conjugating gold film and GNRs with anti-Immunoglobulin G (anti-IgG) antibodies for multiplex detection of various IgG proteins with more than 100nm separation on their SPR wavelengths. |
| first_indexed | 2024-10-01T05:15:05Z |
| format | Conference Paper |
| id | ntu-10356/97756 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:15:05Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/977562020-03-07T13:24:48Z Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection Dinish, U. S. Gong, Tianxun Zeng, Shuwen Olivo, Malini Yong, Ken-Tye School of Electrical and Electronic Engineering Photonics Global Conference (2012 : Singapore) DRNTU::Engineering::Electrical and electronic engineering In this study, we performed finite element method (FEM) simulations to optimize the configuration of gold nanorods (GNR) enhanced surface plasmon resonance (SPR) sensor and discovered its application for multiplex antigens detection. Our work analyzed the near-field coupling between the sensing film and GNR. By systematically study the effect of gold film thickness, GNR-to-film distance and GNR dimensions on SPR, it was found that for GNR width smaller than 40nm, length change in GNR brought about significant SPR wavelength shift on the sensor, while the sensor is insensitive for GNR-to-film distance. As an application, we adopted GNRs of width 20 nm and aspect ratios from 2 to 4 and demonstrated the concept of conjugating gold film and GNRs with anti-Immunoglobulin G (anti-IgG) antibodies for multiplex detection of various IgG proteins with more than 100nm separation on their SPR wavelengths. 2013-07-25T03:17:51Z 2019-12-06T19:46:09Z 2013-07-25T03:17:51Z 2019-12-06T19:46:09Z 2012 2012 Conference Paper Gong, T., Dinish, U. S., Zeng, S., Olivo, M., & Yong, K.-T. (2012). Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection. 2012 Photonics Global Conference (PGC). https://hdl.handle.net/10356/97756 http://hdl.handle.net/10220/12169 10.1109/PGC.2012.6457993 en © 2012 IEEE. |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering Dinish, U. S. Gong, Tianxun Zeng, Shuwen Olivo, Malini Yong, Ken-Tye Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection |
| title | Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection |
| title_full | Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection |
| title_fullStr | Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection |
| title_full_unstemmed | Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection |
| title_short | Optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection |
| title_sort | optimized sandwiched surface plasmon resonance enhanced biosensor for multiplex biomarker detection |
| topic | DRNTU::Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/97756 http://hdl.handle.net/10220/12169 |
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