Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity
In this study, the bone mineral density (BMD), geometry, macroscopic viscoelastic properties and mechanical strength in five different groups of Sprague-Dawley rats (sham operated, ovariectomized with vehicle, parathyroid hormone and/or ibandronate administration) were examined by peripheral quantit...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/97860 http://hdl.handle.net/10220/18058 |
| _version_ | 1811680943049539584 |
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| author | Yang, Xiao Teoh, Swee-Hin DasDe, Shamal Lee, Taeyong |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Yang, Xiao Teoh, Swee-Hin DasDe, Shamal Lee, Taeyong |
| author_sort | Yang, Xiao |
| collection | NTU |
| description | In this study, the bone mineral density (BMD), geometry, macroscopic viscoelastic properties and mechanical strength in five different groups of Sprague-Dawley rats (sham operated, ovariectomized with vehicle, parathyroid hormone and/or ibandronate administration) were examined by peripheral quantitative computed tomography (pQCT), dynamic mechanical analysis (DMA) and three-point bending test. At the end of the study, storage modulus (E′), loss tangent (tan δ), ultimate force (Fu) and stiffness (S) had greatly decreased in vehicle-treated ovariectomized group as compared to sham group (p<0.05). The concurrent administration of parathyroid hormone and ibandronate group exhibited the largest cortical area (Ct.Ar) and thickness (Ct.Th), E′, tan δ (0.3 Hz) and subsequently highest Fu as compared to the mono-therapy groups (p<0.05). However, significant changes were not observed in the BMD values of different groups (p>0.05). The relationships between these potential predictors of bone strength (E′, tan δ, BMD and Ct.Ar) and bone mechanical strength parameters (Fu, S and ultimate stress σu) were also examined. Interestingly, during normal daily activity frequency range (0.9–6 Hz), tan δ and Fu were positively correlated. Taken together, these data suggest that DMA can serve as an effective tool to assess bone strength which would be ignored under the normal clinical screenings due to an unchanged BMD. DMA can therefore be used as a better tool to assess the osteoporotic drug efficacy. |
| first_indexed | 2024-10-01T03:33:04Z |
| format | Journal Article |
| id | ntu-10356/97860 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:33:04Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/978602020-03-07T11:35:35Z Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity Yang, Xiao Teoh, Swee-Hin DasDe, Shamal Lee, Taeyong School of Chemical and Biomedical Engineering In this study, the bone mineral density (BMD), geometry, macroscopic viscoelastic properties and mechanical strength in five different groups of Sprague-Dawley rats (sham operated, ovariectomized with vehicle, parathyroid hormone and/or ibandronate administration) were examined by peripheral quantitative computed tomography (pQCT), dynamic mechanical analysis (DMA) and three-point bending test. At the end of the study, storage modulus (E′), loss tangent (tan δ), ultimate force (Fu) and stiffness (S) had greatly decreased in vehicle-treated ovariectomized group as compared to sham group (p<0.05). The concurrent administration of parathyroid hormone and ibandronate group exhibited the largest cortical area (Ct.Ar) and thickness (Ct.Th), E′, tan δ (0.3 Hz) and subsequently highest Fu as compared to the mono-therapy groups (p<0.05). However, significant changes were not observed in the BMD values of different groups (p>0.05). The relationships between these potential predictors of bone strength (E′, tan δ, BMD and Ct.Ar) and bone mechanical strength parameters (Fu, S and ultimate stress σu) were also examined. Interestingly, during normal daily activity frequency range (0.9–6 Hz), tan δ and Fu were positively correlated. Taken together, these data suggest that DMA can serve as an effective tool to assess bone strength which would be ignored under the normal clinical screenings due to an unchanged BMD. DMA can therefore be used as a better tool to assess the osteoporotic drug efficacy. 2013-12-05T02:14:14Z 2019-12-06T19:47:26Z 2013-12-05T02:14:14Z 2019-12-06T19:47:26Z 2013 2013 Journal Article Yang, X., Teoh, S.-H., DasDe, S., & Lee, T. (2013). Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity. Journal of the mechanical behavior of biomedical materials, 22,51-58. 1751-6161 https://hdl.handle.net/10356/97860 http://hdl.handle.net/10220/18058 10.1016/j.jmbbm.2013.03.009 en Journal of the mechanical behavior of biomedical materials |
| spellingShingle | Yang, Xiao Teoh, Swee-Hin DasDe, Shamal Lee, Taeyong Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity |
| title | Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity |
| title_full | Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity |
| title_fullStr | Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity |
| title_full_unstemmed | Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity |
| title_short | Administration of PTH and ibandronate increases ovariectomized rat compact bone viscoelasticity |
| title_sort | administration of pth and ibandronate increases ovariectomized rat compact bone viscoelasticity |
| url | https://hdl.handle.net/10356/97860 http://hdl.handle.net/10220/18058 |
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