High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants
The use of artificial cornea implants has received increasing attention for treating cornea-related diseases and vision errors due to the low side effects. To achieve long-term successful vision correction, stable and biocompatible materials of high refractive index (RI) need to be developed. Herein...
| Main Authors: | , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/98100 http://hdl.handle.net/10220/12224 |
| _version_ | 1824456036824645632 |
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| author | Chan-Park, Mary B. Beuerman, Roger W. Zhang, Quanyuan Fang, Zheng Cao, Ye Du, Huamao Wu, Hong Duan, Hongwei Xu, Rong |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Chan-Park, Mary B. Beuerman, Roger W. Zhang, Quanyuan Fang, Zheng Cao, Ye Du, Huamao Wu, Hong Duan, Hongwei Xu, Rong |
| author_sort | Chan-Park, Mary B. |
| collection | NTU |
| description | The use of artificial cornea implants has received increasing attention for treating cornea-related diseases and vision errors due to the low side effects. To achieve long-term successful vision correction, stable and biocompatible materials of high refractive index (RI) need to be developed. Herein, we developed an interpenetrating polymer network (IPN) hydrogel containing well-dispersed ZnS nanoparticles (3 nm) covalently linked to the first polymer network, poly(2-hydroethyl methacrylate) (PHEMA). The second polymer network used was poly(acrylic acid) (PAA). The resultant ZnS/PHEMA/PAA IPN nanocomposite is clear and transparent at both dry and hydrated states with their RIs measured to be as high as 1.65 and 1.49, respectively. The equilibrium water content of the hydrogel nanocomposite reached 60.2% which is reasonably near to that of cornea. The material exerted minimal cytotoxicity toward primary epidermal keratinocyte cells. The high RI IPN hydrogel nanocomposite developed here might be an excellent candidate for artificial cornea implants. |
| first_indexed | 2025-02-19T03:47:43Z |
| format | Journal Article |
| id | ntu-10356/98100 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:47:43Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/981002020-03-07T11:35:38Z High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants Chan-Park, Mary B. Beuerman, Roger W. Zhang, Quanyuan Fang, Zheng Cao, Ye Du, Huamao Wu, Hong Duan, Hongwei Xu, Rong School of Chemical and Biomedical Engineering The use of artificial cornea implants has received increasing attention for treating cornea-related diseases and vision errors due to the low side effects. To achieve long-term successful vision correction, stable and biocompatible materials of high refractive index (RI) need to be developed. Herein, we developed an interpenetrating polymer network (IPN) hydrogel containing well-dispersed ZnS nanoparticles (3 nm) covalently linked to the first polymer network, poly(2-hydroethyl methacrylate) (PHEMA). The second polymer network used was poly(acrylic acid) (PAA). The resultant ZnS/PHEMA/PAA IPN nanocomposite is clear and transparent at both dry and hydrated states with their RIs measured to be as high as 1.65 and 1.49, respectively. The equilibrium water content of the hydrogel nanocomposite reached 60.2% which is reasonably near to that of cornea. The material exerted minimal cytotoxicity toward primary epidermal keratinocyte cells. The high RI IPN hydrogel nanocomposite developed here might be an excellent candidate for artificial cornea implants. 2013-07-25T06:03:06Z 2019-12-06T19:50:32Z 2013-07-25T06:03:06Z 2019-12-06T19:50:32Z 2012 2012 Journal Article Zhang, Q., Fang, Z., Cao, Y., Du, H., Wu, H., Beuerman, R. W., et al. (2012). High Refractive Index Inorganic–Organic Interpenetrating Polymer Network (IPN) Hydrogel Nanocomposite toward Artificial Cornea Implants. ACS Macro Letters, 1(7), 876-881. https://hdl.handle.net/10356/98100 http://hdl.handle.net/10220/12224 10.1021/mz300078y en ACS macro letters © 2012 American Chemical Society. |
| spellingShingle | Chan-Park, Mary B. Beuerman, Roger W. Zhang, Quanyuan Fang, Zheng Cao, Ye Du, Huamao Wu, Hong Duan, Hongwei Xu, Rong High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants |
| title | High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants |
| title_full | High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants |
| title_fullStr | High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants |
| title_full_unstemmed | High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants |
| title_short | High refractive index inorganic–organic Interpenetrating Polymer Network (IPN) hydrogel nanocomposite toward artificial cornea implants |
| title_sort | high refractive index inorganic organic interpenetrating polymer network ipn hydrogel nanocomposite toward artificial cornea implants |
| url | https://hdl.handle.net/10356/98100 http://hdl.handle.net/10220/12224 |
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