A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing
A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by opt...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
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2015
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/98112 http://hdl.handle.net/10220/38537 |
| _version_ | 1826115915960287232 |
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| author | Wang, Fei Yu, Hao Yeo, Kiat Seng Guo, Jing Huang, Xiwei Yan, Mei |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Wang, Fei Yu, Hao Yeo, Kiat Seng Guo, Jing Huang, Xiwei Yan, Mei |
| author_sort | Wang, Fei |
| collection | NTU |
| description | A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate correlation. Moreover, pixel-to-pixel ISFET threshold voltage mismatch is reduced by correlated double sampling (CDS) readout. Measurements show a sensitivity of 103.8mV/pH and fixed-pattern-noise (FPN) reduction from 4% to 0.3% with speed of 1200fps. . |
| first_indexed | 2024-10-01T04:02:55Z |
| format | Conference Paper |
| id | ntu-10356/98112 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:02:55Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/981122020-03-07T13:24:48Z A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing Wang, Fei Yu, Hao Yeo, Kiat Seng Guo, Jing Huang, Xiwei Yan, Mei School of Electrical and Electronic Engineering 2014 Symposium on VLSI Circuits Digest of Technical Papers DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits A 64×64 CMOS ion-image sensor is demonstrated towards accurate high-throughput DNA sequencing. Dual-mode (pH/image) sensing is performed with ion-sensitive field-effect transistor (ISFET) fabricated in standard CMOS image sensor (CIS) process. After addressing physical locations of DNA slices by optical contact imaging, local pH for one DNA slice can be mapped to its physical address with accurate correlation. Moreover, pixel-to-pixel ISFET threshold voltage mismatch is reduced by correlated double sampling (CDS) readout. Measurements show a sensitivity of 103.8mV/pH and fixed-pattern-noise (FPN) reduction from 4% to 0.3% with speed of 1200fps. . Accepted version 2015-08-27T09:00:57Z 2019-12-06T19:50:42Z 2015-08-27T09:00:57Z 2019-12-06T19:50:42Z 2014 2014 Conference Paper Huang, X., Wang, F., Guo, J., Yan, M., Yu, H., & Yeo, K. S. (2014). A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing. 2014 Symposium on VLSI Circuits Digest of Technical Papers. https://hdl.handle.net/10356/98112 http://hdl.handle.net/10220/38537 10.1109/VLSIC.2014.6858409 en © 2014 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works. The published version is available at: [http://dx.doi.org/10.1109/VLSIC.2014.6858409]. 4 p. application/pdf |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits Wang, Fei Yu, Hao Yeo, Kiat Seng Guo, Jing Huang, Xiwei Yan, Mei A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing |
| title | A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing |
| title_full | A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing |
| title_fullStr | A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing |
| title_full_unstemmed | A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing |
| title_short | A 64×64 1200fps CMOS ion-image sensor with suppressed fixed-pattern-noise for accurate high-throughput DNA sequencing |
| title_sort | 64 64 1200fps cmos ion image sensor with suppressed fixed pattern noise for accurate high throughput dna sequencing |
| topic | DRNTU::Engineering::Electrical and electronic engineering::Integrated circuits |
| url | https://hdl.handle.net/10356/98112 http://hdl.handle.net/10220/38537 |
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