Lab-in-fiber platform for plasmonic photothermal study
A lab-in-fiber platform, comprising a photonic crystal fiber component for light-sample interaction, was experimentally demonstrated to be effective as a sensor and micro-reactor. Specifically, it enabled the discrimination between free and liposome-encapsulated fluorophores as well as allowed for t...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/98188 http://hdl.handle.net/10220/13347 |
| _version_ | 1826117807187689472 |
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| author | Yong, Derrick Lee, Elizabeth Ng, Wei Long Yu, Xia Chan, Chi Chiu |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Yong, Derrick Lee, Elizabeth Ng, Wei Long Yu, Xia Chan, Chi Chiu |
| author_sort | Yong, Derrick |
| collection | NTU |
| description | A lab-in-fiber platform, comprising a photonic crystal fiber component for light-sample interaction, was experimentally demonstrated to be effective as a sensor and micro-reactor. Specifically, it enabled the discrimination between free and liposome-encapsulated fluorophores as well as allowed for the excitation of in-fiber plasmonic photothermal effects, by alternating between different fiber-coupled inputs. The significant increase in fluorescence emissions upon release of fluorophores, encapsulated within liposomes at self-quenching concentrations, was perceived as a shoulder in the device’s spectral output that otherwise only comprises the input excitation. Markedly, the observed shoulder was only discernible when the photonic crystal fiber was placed in a bent orientation. This was explained to be associated with the bending-induced refractive index profile changes in the fiber cross section that led to increased amounts of evanescent fields for light-sample interactions. Results highlighted the viability of the lab-in-fiber platform as an alternative to current lab-on-a-chip devices. |
| first_indexed | 2024-10-01T04:33:23Z |
| format | Conference Paper |
| id | ntu-10356/98188 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:33:23Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/981882020-09-26T22:10:30Z Lab-in-fiber platform for plasmonic photothermal study Yong, Derrick Lee, Elizabeth Ng, Wei Long Yu, Xia Chan, Chi Chiu School of Chemical and Biomedical Engineering Microfluidics, BioMEMS, and Medical Microsystems (11th : 2013 : San Francisco, USA) A*STAR SIMTech A lab-in-fiber platform, comprising a photonic crystal fiber component for light-sample interaction, was experimentally demonstrated to be effective as a sensor and micro-reactor. Specifically, it enabled the discrimination between free and liposome-encapsulated fluorophores as well as allowed for the excitation of in-fiber plasmonic photothermal effects, by alternating between different fiber-coupled inputs. The significant increase in fluorescence emissions upon release of fluorophores, encapsulated within liposomes at self-quenching concentrations, was perceived as a shoulder in the device’s spectral output that otherwise only comprises the input excitation. Markedly, the observed shoulder was only discernible when the photonic crystal fiber was placed in a bent orientation. This was explained to be associated with the bending-induced refractive index profile changes in the fiber cross section that led to increased amounts of evanescent fields for light-sample interactions. Results highlighted the viability of the lab-in-fiber platform as an alternative to current lab-on-a-chip devices. Published version 2013-09-05T08:19:47Z 2019-12-06T19:51:55Z 2013-09-05T08:19:47Z 2019-12-06T19:51:55Z 2013 2013 Conference Paper Yong, D., Lee, E., Ng, W. L., Yu, X.,& Chan, C. C. (2013). Lab-in-fiber platform for plasmonic photothermal study. Proceeding of SPIE 8615, Microfluidics, BioMEMS, and Medical Microsystems XI, 861504. https://hdl.handle.net/10356/98188 http://hdl.handle.net/10220/13347 10.1117/12.2003335 en © 2013 Society of Photo-Optical Instrumentation Engineers (SPIE). This paper was published in Proceeding of SPIE, Microfluidics, BioMEMS, and Medical Microsystems XI and is made available as an electronic reprint (preprint) with permission of SPIE. The paper can be found at the following official DOI: [http://dx.doi.org/10.1117/12.2003335]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. application/pdf |
| spellingShingle | Yong, Derrick Lee, Elizabeth Ng, Wei Long Yu, Xia Chan, Chi Chiu Lab-in-fiber platform for plasmonic photothermal study |
| title | Lab-in-fiber platform for plasmonic photothermal study |
| title_full | Lab-in-fiber platform for plasmonic photothermal study |
| title_fullStr | Lab-in-fiber platform for plasmonic photothermal study |
| title_full_unstemmed | Lab-in-fiber platform for plasmonic photothermal study |
| title_short | Lab-in-fiber platform for plasmonic photothermal study |
| title_sort | lab in fiber platform for plasmonic photothermal study |
| url | https://hdl.handle.net/10356/98188 http://hdl.handle.net/10220/13347 |
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