Continuous sorting of microparticles using dielectrophoresis
Sorting of particles such as cells is a critical process for many biomedical applications, and it is challenging to integrate it into an analytical microdevice. We report an effective and flexible dielectrophoresis (DEP)-based microfluidic device for continuous sorting of multiple particles in a mic...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/98207 http://hdl.handle.net/10220/13664 |
| _version_ | 1826115534522941440 |
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| author | Chen, D. F. Li, W. H. Li, M. Du, Hejun |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Chen, D. F. Li, W. H. Li, M. Du, Hejun |
| author_sort | Chen, D. F. |
| collection | NTU |
| description | Sorting of particles such as cells is a critical process for many biomedical applications, and it is challenging to integrate it into an analytical microdevice. We report an effective and flexible dielectrophoresis (DEP)-based microfluidic device for continuous sorting of multiple particles in a microchannel. The particle sorter is composed of two components—a DEP focusing unit and a Movable DEP Trap (MDT). The trap is formed by an array of microelectrodes at the bottom of the channel and a transparent electrode plate placed at the top. The location of the trap is dependent on the configuration of voltages on the array and therefore is addressable. Flowing particles are first directed and focused into a single particle stream by the focusing unit. The streamed particles are then sorted into different fractions using the movable trap by rapidly switching the applied voltage. The performance of the sorter is demonstrated by successfully sorting microparticles in a continuous flow. The proposed DEP-based microfluidic sorter can be implemented in applications such as sample preparation and cell sorting for subsequent analytical processing, where sorting of particles is needed. |
| first_indexed | 2024-10-01T03:56:44Z |
| format | Journal Article |
| id | ntu-10356/98207 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:56:44Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/982072020-03-07T13:22:18Z Continuous sorting of microparticles using dielectrophoresis Chen, D. F. Li, W. H. Li, M. Du, Hejun School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering Sorting of particles such as cells is a critical process for many biomedical applications, and it is challenging to integrate it into an analytical microdevice. We report an effective and flexible dielectrophoresis (DEP)-based microfluidic device for continuous sorting of multiple particles in a microchannel. The particle sorter is composed of two components—a DEP focusing unit and a Movable DEP Trap (MDT). The trap is formed by an array of microelectrodes at the bottom of the channel and a transparent electrode plate placed at the top. The location of the trap is dependent on the configuration of voltages on the array and therefore is addressable. Flowing particles are first directed and focused into a single particle stream by the focusing unit. The streamed particles are then sorted into different fractions using the movable trap by rapidly switching the applied voltage. The performance of the sorter is demonstrated by successfully sorting microparticles in a continuous flow. The proposed DEP-based microfluidic sorter can be implemented in applications such as sample preparation and cell sorting for subsequent analytical processing, where sorting of particles is needed. 2013-09-24T07:37:45Z 2019-12-06T19:52:04Z 2013-09-24T07:37:45Z 2019-12-06T19:52:04Z 2012 2012 Journal Article Chen, D. F., Li, W. H., Du, H., & Li, M. (2012). Continuous sorting of microparticles using dielectrophoresis. Journal of nanoscience and nanotechnology, 12(4), 3035-3039(5). https://hdl.handle.net/10356/98207 http://hdl.handle.net/10220/13664 10.1166/jnn.2012.5828 en Journal of nanoscience and nanotechnology |
| spellingShingle | DRNTU::Engineering::Mechanical engineering Chen, D. F. Li, W. H. Li, M. Du, Hejun Continuous sorting of microparticles using dielectrophoresis |
| title | Continuous sorting of microparticles using dielectrophoresis |
| title_full | Continuous sorting of microparticles using dielectrophoresis |
| title_fullStr | Continuous sorting of microparticles using dielectrophoresis |
| title_full_unstemmed | Continuous sorting of microparticles using dielectrophoresis |
| title_short | Continuous sorting of microparticles using dielectrophoresis |
| title_sort | continuous sorting of microparticles using dielectrophoresis |
| topic | DRNTU::Engineering::Mechanical engineering |
| url | https://hdl.handle.net/10356/98207 http://hdl.handle.net/10220/13664 |
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