Solution structure of FK506-binding protein 12 from Aedes aegypti
Dengue remains one of the major public concerns as the virus eludes the immune response. Currently, no vaccines or antiviral therapeutics are available for dengue prevention or treatment. Immunosuppressive drug FK506 shows an antimalarial activity, and its molecular target, FK506-binding protein (FK...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/98219 http://hdl.handle.net/10220/12368 |
| _version_ | 1826127236603838464 |
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| author | Chakraborty, Goutam Shin, Joon Nguyen, Quoc Toan Harikishore, Amaravadhi Baek, Kwanghee Yoon, Ho Sup |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Chakraborty, Goutam Shin, Joon Nguyen, Quoc Toan Harikishore, Amaravadhi Baek, Kwanghee Yoon, Ho Sup |
| author_sort | Chakraborty, Goutam |
| collection | NTU |
| description | Dengue remains one of the major public concerns as the virus eludes the immune response. Currently, no vaccines or antiviral therapeutics are available for dengue prevention or treatment. Immunosuppressive drug FK506 shows an antimalarial activity, and its molecular target, FK506-binding protein (FKBP), was identified in human Plasmodium parasites. Likewise, a conserved FKBP family protein has also been identified in Aedes aegypti (AaFKBP12), which is expected to play a similar role in the life cycle of Aedes aegypti, the primary vector of dengue virus infection. As FKBPs belong to a highly conserved class of immunophilin family and are involved in key biological regulations, they are considered as attractive pharmacological targets. In this study, we have determined the nuclear magnetic resonance solution structure of AaFKBP12, a novel FKBP member from Aedes aegypti, and presented its structural features, which may facilitate the design of potential inhibitory ligands against the dengue-transmitting mosquitoes. |
| first_indexed | 2024-10-01T07:05:30Z |
| format | Journal Article |
| id | ntu-10356/98219 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:05:30Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/982192020-03-07T12:18:19Z Solution structure of FK506-binding protein 12 from Aedes aegypti Chakraborty, Goutam Shin, Joon Nguyen, Quoc Toan Harikishore, Amaravadhi Baek, Kwanghee Yoon, Ho Sup School of Biological Sciences DRNTU::Science::Biological sciences Dengue remains one of the major public concerns as the virus eludes the immune response. Currently, no vaccines or antiviral therapeutics are available for dengue prevention or treatment. Immunosuppressive drug FK506 shows an antimalarial activity, and its molecular target, FK506-binding protein (FKBP), was identified in human Plasmodium parasites. Likewise, a conserved FKBP family protein has also been identified in Aedes aegypti (AaFKBP12), which is expected to play a similar role in the life cycle of Aedes aegypti, the primary vector of dengue virus infection. As FKBPs belong to a highly conserved class of immunophilin family and are involved in key biological regulations, they are considered as attractive pharmacological targets. In this study, we have determined the nuclear magnetic resonance solution structure of AaFKBP12, a novel FKBP member from Aedes aegypti, and presented its structural features, which may facilitate the design of potential inhibitory ligands against the dengue-transmitting mosquitoes. 2013-07-26T04:17:27Z 2019-12-06T19:52:12Z 2013-07-26T04:17:27Z 2019-12-06T19:52:12Z 2012 2012 Journal Article Chakraborty, G., Shin, J., Nguyen, Q. T., Harikishore, A., Baek, K., & Yoon, H. S. (2012). Solution structure of FK506-binding protein 12 from Aedes aegypti . Proteins: Structure, Function, and Bioinformatics, 80(10), 2476-2481. 0887-3585 https://hdl.handle.net/10356/98219 http://hdl.handle.net/10220/12368 10.1002/prot.24146 en Proteins: structure, function, and bioinformatics © 2012 Wiley Periodicals, Inc. |
| spellingShingle | DRNTU::Science::Biological sciences Chakraborty, Goutam Shin, Joon Nguyen, Quoc Toan Harikishore, Amaravadhi Baek, Kwanghee Yoon, Ho Sup Solution structure of FK506-binding protein 12 from Aedes aegypti |
| title | Solution structure of FK506-binding protein 12 from Aedes aegypti |
| title_full | Solution structure of FK506-binding protein 12 from Aedes aegypti |
| title_fullStr | Solution structure of FK506-binding protein 12 from Aedes aegypti |
| title_full_unstemmed | Solution structure of FK506-binding protein 12 from Aedes aegypti |
| title_short | Solution structure of FK506-binding protein 12 from Aedes aegypti |
| title_sort | solution structure of fk506 binding protein 12 from aedes aegypti |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/98219 http://hdl.handle.net/10220/12368 |
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