Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

Bruton's tyrosine kinase phosphorylates Toll-like receptor 3 to initiate antiviral response

Toll-like receptor 3 (TLR3) mediates antiviral response by recognizing double-stranded RNA. Its cytoplasmic domain is tyrosine phosphorylated upon ligand binding and initiates downstream signaling via the adapter TIR-containing adaptor inducing interferon–β (TRIF). However, the kinase responsible fo...

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Bibliographic Details
Main Authors: Lee, K.-G., Xu, S., Kang, Z.-H., Huo, J., Huang, M., Liu, D., Takeuchi, O., Lam, K.-P., Akira, Shizuo
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2013
Subjects:
DRNTU::Science::Biological sciences
Online Access:https://hdl.handle.net/10356/98238
http://hdl.handle.net/10220/12357

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