Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium
2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activ...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/98283 http://hdl.handle.net/10220/12334 |
| _version_ | 1826113191240794112 |
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| author | Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi |
| author_sort | Ilies, Laurean |
| collection | NTU |
| description | 2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%). |
| first_indexed | 2024-10-01T03:19:09Z |
| format | Journal Article |
| id | ntu-10356/98283 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:19:09Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/982832020-03-07T12:34:46Z Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi School of Physical and Mathematical Sciences 2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 °C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this CH bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%). 2013-07-26T01:51:46Z 2019-12-06T19:53:09Z 2013-07-26T01:51:46Z 2019-12-06T19:53:09Z 2012 2012 Journal Article Ilies, L., Kobayashi, M., Matsumoto, A., Yoshikai, N., & Nakamura, E. (2012). Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium. Advanced Synthesis & Catalysis, 354(4), 593-596. 1615-4150 https://hdl.handle.net/10356/98283 http://hdl.handle.net/10220/12334 10.1002/adsc.201100791 en Advanced synthesis & catalysis © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | Ilies, Laurean Kobayashi, Motoaki Matsumoto, Arimasa Yoshikai, Naohiko Nakamura, Eiichi Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
| title | Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
| title_full | Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
| title_fullStr | Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
| title_full_unstemmed | Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
| title_short | Iron-catalyzed nitrogen-directed coupling of arene and aryl bromides mediated by metallic magnesium |
| title_sort | iron catalyzed nitrogen directed coupling of arene and aryl bromides mediated by metallic magnesium |
| url | https://hdl.handle.net/10356/98283 http://hdl.handle.net/10220/12334 |
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