Palladium-catalyzed direct C-H arylation of enamides with simple arenes
Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential se...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/98400 http://hdl.handle.net/10220/12496 |
| _version_ | 1826118302627266560 |
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| author | Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng |
| author_sort | Pankajakshan, Sreekumar |
| collection | NTU |
| description | Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B). |
| first_indexed | 2024-10-01T04:41:30Z |
| format | Journal Article |
| id | ntu-10356/98400 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:41:30Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/984002020-03-07T12:34:47Z Palladium-catalyzed direct C-H arylation of enamides with simple arenes Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Z only: An atom-economical synthetic route towards arylated Z-enamides through double CH functionalization is described. The Z/E selectivity of the palladium-catalyzed monoarylation is absolute (step A in scheme), and the molecular complexity of the products can be further endowed by a sequential second arylation, which requires the use of trifluoracetic acid (TFA; step B). 2013-07-29T08:11:12Z 2019-12-06T19:54:51Z 2013-07-29T08:11:12Z 2019-12-06T19:54:51Z 2012 2012 Journal Article Pankajakshan, S., Xu, Y.-H., Cheng, J. K., Low, M. T., & Loh, T.-P. (2012). Palladium-Catalyzed Direct C-H Arylation of Enamides with Simple Arenes. Angewandte Chemie International Edition, 51(23), 5701-5705. 1433-7851 https://hdl.handle.net/10356/98400 http://hdl.handle.net/10220/12496 10.1002/anie.201109247 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Science::Chemistry Pankajakshan, Sreekumar Xu, Yun-He Cheng, Jun Kee Low, Man Ting Loh, Teck-Peng Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title | Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_full | Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_fullStr | Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_full_unstemmed | Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_short | Palladium-catalyzed direct C-H arylation of enamides with simple arenes |
| title_sort | palladium catalyzed direct c h arylation of enamides with simple arenes |
| topic | DRNTU::Science::Chemistry |
| url | https://hdl.handle.net/10356/98400 http://hdl.handle.net/10220/12496 |
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