Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex
Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine–pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room t...
| Principais autores: | , |
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| Outros Autores: | |
| Formato: | Journal Article |
| Idioma: | English |
| Publicado em: |
2013
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| Acesso em linha: | https://hdl.handle.net/10356/98454 http://hdl.handle.net/10220/12470 |
| _version_ | 1826130642716327936 |
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| author | Ding, Zhenhua Yoshikai, Naohiko |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Ding, Zhenhua Yoshikai, Naohiko |
| author_sort | Ding, Zhenhua |
| collection | NTU |
| description | Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine–pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme). |
| first_indexed | 2024-10-01T07:59:18Z |
| format | Journal Article |
| id | ntu-10356/98454 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:59:18Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/984542020-03-07T12:34:47Z Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex Ding, Zhenhua Yoshikai, Naohiko School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Direct alkenylation of the C2-position of indoles bearing an easily removable N-pyrimidyl group with alkynes has been achieved by using a cobalt catalyst complexed with a phosphine–pyridine bidentate ligand. This reaction has wide substrate scope and is highly efficient and stereoselective at room temperature. The alkenylated indoles serve as useful platforms for further synthetic transformations (some products of these transformations are shown in the scheme). 2013-07-29T06:55:44Z 2019-12-06T19:55:24Z 2013-07-29T06:55:44Z 2019-12-06T19:55:24Z 2012 2012 Journal Article Ding, Z., & Yoshikai, N. (2012). Mild and Efficient C2-Alkenylation of Indoles with Alkynes Catalyzed by a Cobalt Complex. Angewandte Chemie International Edition, 51(19), 4698-4701. 1433-7851 https://hdl.handle.net/10356/98454 http://hdl.handle.net/10220/12470 10.1002/anie.201200019 en Angewandte chemie international edition © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Science::Chemistry Ding, Zhenhua Yoshikai, Naohiko Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex |
| title | Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex |
| title_full | Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex |
| title_fullStr | Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex |
| title_full_unstemmed | Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex |
| title_short | Mild and efficient C2-alkenylation of indoles with alkynes catalyzed by a cobalt complex |
| title_sort | mild and efficient c2 alkenylation of indoles with alkynes catalyzed by a cobalt complex |
| topic | DRNTU::Science::Chemistry |
| url | https://hdl.handle.net/10356/98454 http://hdl.handle.net/10220/12470 |
| work_keys_str_mv | AT dingzhenhua mildandefficientc2alkenylationofindoleswithalkynescatalyzedbyacobaltcomplex AT yoshikainaohiko mildandefficientc2alkenylationofindoleswithalkynescatalyzedbyacobaltcomplex |