Following G-quadruplex formation by its intrinsic fluorescence

We characterized and compared the fluorescence properties of various well-defined G-quadruplex structures. The increase of intrinsic fluorescence of G-rich DNA sequences when they form G-quadruplexes can be used to monitor the folding and unfolding of G-quadruplexes as a function of cations and temp...

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Detalles Bibliográficos
Autores principales: Dao, Nguyen Thuan, Reinhard, Haselsberger, Maria-Elisabeth, Michel-Beyerle, Phan, Anh Tuân
Otros Autores: School of Physical and Mathematical Sciences
Formato: Journal Article
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://hdl.handle.net/10356/98618
http://hdl.handle.net/10220/12476
Descripción
Sumario:We characterized and compared the fluorescence properties of various well-defined G-quadruplex structures. The increase of intrinsic fluorescence of G-rich DNA sequences when they form G-quadruplexes can be used to monitor the folding and unfolding of G-quadruplexes as a function of cations and temperature. The temperature-dependent fluorescence spectra of different G-quadruplexes also exhibit characteristic patterns. Thus, the stability and possibly also the structure of G-quadruplexes can be characterized and distinguished by their intrinsic fluorescence spectra.