An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study
Individualized disease treatment is a promising branch for future medicine. In this work, we introduce an implantable microelectromechanical system (MEMS) based drug delivery device for programmable drug delivery. An in vitro study on cancer cell treatment has been conducted to demonstrate a proof-o...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/98679 http://hdl.handle.net/10220/17435 |
| _version_ | 1826119344207167488 |
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| author | Song, Peiyi Tng, Danny Jian Hang Hu, Rui Lin, Guimiao Meng, Ellis Yong, Ken-Tye |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Song, Peiyi Tng, Danny Jian Hang Hu, Rui Lin, Guimiao Meng, Ellis Yong, Ken-Tye |
| author_sort | Song, Peiyi |
| collection | NTU |
| description | Individualized disease treatment is a promising branch for future medicine. In this work, we introduce an implantable microelectromechanical system (MEMS) based drug delivery device for programmable drug delivery. An in vitro study on cancer cell treatment has been conducted to demonstrate a proof-of-concept that the engineered device is suitable for individualized disease treatment. This is the first study to demonstrate that MEMS drug delivery devices can influence the outcome of cancer drug treatment through the use of individualized disease treatment regimes, where the strategy for drug dosages is tailored according to different individuals. The presented device is electrochemically actuated through a diaphragm membrane and made of polydimethylsiloxane (PDMS) for biocompatibility using simple and cost-effective microfabrication techniques. Individualized disease treatment was investigated using the in vitro programmed delivery of a chemotherapy drug, doxorubicin, to pancreatic cancer cell cultures. Cultured cell colonies of two pancreatic cancer cell lines (Panc-1 and MiaPaCa-2) were treated with three programmed schedules and monitored for 7 days. The result shows that the colony growth has been successfully inhibited for both cell lines among all the three treatment schedules. Also, the different observations between the two cell lines under different schedules reveal that MiaPaCa-2 cells are more sensitive to the drug applied. These results demonstrate that further development on the device will provide a promising novel platform for individualized disease treatment in future medicine as well as for automatic in vitro assays in drug development industry. |
| first_indexed | 2024-10-01T04:58:45Z |
| format | Journal Article |
| id | ntu-10356/98679 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:58:45Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/986792020-03-07T13:57:31Z An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study Song, Peiyi Tng, Danny Jian Hang Hu, Rui Lin, Guimiao Meng, Ellis Yong, Ken-Tye School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering Individualized disease treatment is a promising branch for future medicine. In this work, we introduce an implantable microelectromechanical system (MEMS) based drug delivery device for programmable drug delivery. An in vitro study on cancer cell treatment has been conducted to demonstrate a proof-of-concept that the engineered device is suitable for individualized disease treatment. This is the first study to demonstrate that MEMS drug delivery devices can influence the outcome of cancer drug treatment through the use of individualized disease treatment regimes, where the strategy for drug dosages is tailored according to different individuals. The presented device is electrochemically actuated through a diaphragm membrane and made of polydimethylsiloxane (PDMS) for biocompatibility using simple and cost-effective microfabrication techniques. Individualized disease treatment was investigated using the in vitro programmed delivery of a chemotherapy drug, doxorubicin, to pancreatic cancer cell cultures. Cultured cell colonies of two pancreatic cancer cell lines (Panc-1 and MiaPaCa-2) were treated with three programmed schedules and monitored for 7 days. The result shows that the colony growth has been successfully inhibited for both cell lines among all the three treatment schedules. Also, the different observations between the two cell lines under different schedules reveal that MiaPaCa-2 cells are more sensitive to the drug applied. These results demonstrate that further development on the device will provide a promising novel platform for individualized disease treatment in future medicine as well as for automatic in vitro assays in drug development industry. 2013-11-08T03:37:28Z 2019-12-06T19:58:24Z 2013-11-08T03:37:28Z 2019-12-06T19:58:24Z 2013 2013 Journal Article Song, P., Tng, D. J. H., Hu, R., Lin, G., Meng, E., & Yong, K.-T. (2013). An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study. Advanced healthcare materials, 2(8), 1170-1178. 2192-2640 https://hdl.handle.net/10356/98679 http://hdl.handle.net/10220/17435 10.1002/adhm.201200356 en Advanced healthcare materials |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering Song, Peiyi Tng, Danny Jian Hang Hu, Rui Lin, Guimiao Meng, Ellis Yong, Ken-Tye An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study |
| title | An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study |
| title_full | An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study |
| title_fullStr | An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study |
| title_full_unstemmed | An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study |
| title_short | An electrochemically actuated MEMS device for individualized drug delivery : an in vitro study |
| title_sort | electrochemically actuated mems device for individualized drug delivery an in vitro study |
| topic | DRNTU::Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/98679 http://hdl.handle.net/10220/17435 |
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