Magnetic fields facilitate DNA-mediated charge transport
Exaggerated radical-induced DNA damage under magnetic fields is of great concern to medical biosafety and biomolecular electronic devices. In this report, the effects of an external magnetic field (MF) on DNA electronic conductivity were investigated by studying the efficiencies of photoinduced DNA-...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2015
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| Online Access: | https://hdl.handle.net/10356/98730 http://hdl.handle.net/10220/38541 |
| _version_ | 1826127456999833600 |
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| author | Lee, Kee Jin Shu, Jian-Jun Shao, Fangwei Wong, Jiun Ru |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Lee, Kee Jin Shu, Jian-Jun Shao, Fangwei Wong, Jiun Ru |
| author_sort | Lee, Kee Jin |
| collection | NTU |
| description | Exaggerated radical-induced DNA damage under magnetic fields is of great concern to medical biosafety and biomolecular electronic devices. In this report, the effects of an external magnetic field (MF) on DNA electronic conductivity were investigated by studying the efficiencies of photoinduced DNA-mediated charge transport (CT) via guanine damage. Under a static MF of 300 mT, positive enhancements in the decomposition of 8-cyclopropyldeoxyguanosine (8CPG) were observed at both the proximal and distal guanine doublets, indicating a more efficient propagation of radical cations and higher electronic conductivity of duplex DNA. MF-assisted CT has shown sensitivity to magnetic field strength, duplex structures, and the integrity of base pair stacking. Spin evolution of charge injection and the alignment of base pairs to the CT-active conformation during radical propagation were proposed to be the two major factors that MF contributes to facilitate DNA-mediated CT. Herein, MF-assisted CT may offer a new avenue for designing DNA-based electronic devices and unraveling MF effects on redox and radical relevant biological processes. |
| first_indexed | 2024-10-01T07:08:52Z |
| format | Journal Article |
| id | ntu-10356/98730 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:08:52Z |
| publishDate | 2015 |
| record_format | dspace |
| spelling | ntu-10356/987302023-02-28T19:37:03Z Magnetic fields facilitate DNA-mediated charge transport Lee, Kee Jin Shu, Jian-Jun Shao, Fangwei Wong, Jiun Ru School of Mechanical and Aerospace Engineering School of Physical and Mathematical Sciences Exaggerated radical-induced DNA damage under magnetic fields is of great concern to medical biosafety and biomolecular electronic devices. In this report, the effects of an external magnetic field (MF) on DNA electronic conductivity were investigated by studying the efficiencies of photoinduced DNA-mediated charge transport (CT) via guanine damage. Under a static MF of 300 mT, positive enhancements in the decomposition of 8-cyclopropyldeoxyguanosine (8CPG) were observed at both the proximal and distal guanine doublets, indicating a more efficient propagation of radical cations and higher electronic conductivity of duplex DNA. MF-assisted CT has shown sensitivity to magnetic field strength, duplex structures, and the integrity of base pair stacking. Spin evolution of charge injection and the alignment of base pairs to the CT-active conformation during radical propagation were proposed to be the two major factors that MF contributes to facilitate DNA-mediated CT. Herein, MF-assisted CT may offer a new avenue for designing DNA-based electronic devices and unraveling MF effects on redox and radical relevant biological processes. Accepted version 2015-09-01T03:25:34Z 2019-12-06T19:58:56Z 2015-09-01T03:25:34Z 2019-12-06T19:58:56Z 2015 2015 Journal Article Wong, J. R., Lee, K. J., Shu, J.-J., & Shao, F. (2015). Magnetic fields facilitate DNA-mediated charge transport. Biochemistry, 54(21), 3392-3399. https://hdl.handle.net/10356/98730 http://hdl.handle.net/10220/38541 10.1021/acs.biochem.5b00295 186034 en Biochemistry © 2015 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Biochemistry, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.biochem.5b00295]. application/pdf |
| spellingShingle | Lee, Kee Jin Shu, Jian-Jun Shao, Fangwei Wong, Jiun Ru Magnetic fields facilitate DNA-mediated charge transport |
| title | Magnetic fields facilitate DNA-mediated charge transport |
| title_full | Magnetic fields facilitate DNA-mediated charge transport |
| title_fullStr | Magnetic fields facilitate DNA-mediated charge transport |
| title_full_unstemmed | Magnetic fields facilitate DNA-mediated charge transport |
| title_short | Magnetic fields facilitate DNA-mediated charge transport |
| title_sort | magnetic fields facilitate dna mediated charge transport |
| url | https://hdl.handle.net/10356/98730 http://hdl.handle.net/10220/38541 |
| work_keys_str_mv | AT leekeejin magneticfieldsfacilitatednamediatedchargetransport AT shujianjun magneticfieldsfacilitatednamediatedchargetransport AT shaofangwei magneticfieldsfacilitatednamediatedchargetransport AT wongjiunru magneticfieldsfacilitatednamediatedchargetransport |