Review of confocal fluorescence endomicroscopy for cancer detection
The cancer burden is increasing worldwide and there is a need to develop new technologies for cancer diagnosis. Confocal laser endomicroscopy (CLE) is a minimally invasive optical technique that enables in vivo confocal imaging of tissue structures. With the use of fluorescent dyes, the technique al...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/99001 http://hdl.handle.net/10220/13443 |
| _version_ | 1811680332651429888 |
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| author | Thong, Patricia Soo-Ping Olivo, Malini Tandjung, Stephanus Surijadarma Movania, Muhammad Mobeen Lin, Feng Qian, Kemao Seah, Hock Soon Soo, Khee-Chee |
| author2 | School of Computer Engineering |
| author_facet | School of Computer Engineering Thong, Patricia Soo-Ping Olivo, Malini Tandjung, Stephanus Surijadarma Movania, Muhammad Mobeen Lin, Feng Qian, Kemao Seah, Hock Soon Soo, Khee-Chee |
| author_sort | Thong, Patricia Soo-Ping |
| collection | NTU |
| description | The cancer burden is increasing worldwide and there is a need to develop new technologies for cancer diagnosis. Confocal laser endomicroscopy (CLE) is a minimally invasive optical technique that enables in vivo confocal imaging of tissue structures. With the use of fluorescent dyes, the technique allows confocal fluorescence endomicroscopy of tissue from surface to subsurface layers. CLE has been applied to the surveillance and diagnosis of cancer in numerous clinical studies recently, and also holds potential for optical and guided biopsy procedures. The first part of this mini review is focused on the application of CLE for cancer detection and surveillance. The second part is focused on the application of CLE to imaging of the oral cavity. We have previously demonstrated the potential of CLE for diagnostic imaging of oral cavity lesions. To move toward real-time 3-D imaging, we interfaced an endomicroscope to an embedded computing system. The prototype system is capable of automated image acquisition and real-time volume rendering. Rendering results provide topographical and depth information. Our aim is to achieve a real-time 3-D fluorescence imaging system that can be used for diagnostic imaging and guided biopsy procedures of oral cavity lesions in a clinical setting. |
| first_indexed | 2024-10-01T03:23:22Z |
| format | Journal Article |
| id | ntu-10356/99001 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:23:22Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/990012020-05-28T07:18:49Z Review of confocal fluorescence endomicroscopy for cancer detection Thong, Patricia Soo-Ping Olivo, Malini Tandjung, Stephanus Surijadarma Movania, Muhammad Mobeen Lin, Feng Qian, Kemao Seah, Hock Soon Soo, Khee-Chee School of Computer Engineering DRNTU::Engineering::Computer science and engineering The cancer burden is increasing worldwide and there is a need to develop new technologies for cancer diagnosis. Confocal laser endomicroscopy (CLE) is a minimally invasive optical technique that enables in vivo confocal imaging of tissue structures. With the use of fluorescent dyes, the technique allows confocal fluorescence endomicroscopy of tissue from surface to subsurface layers. CLE has been applied to the surveillance and diagnosis of cancer in numerous clinical studies recently, and also holds potential for optical and guided biopsy procedures. The first part of this mini review is focused on the application of CLE for cancer detection and surveillance. The second part is focused on the application of CLE to imaging of the oral cavity. We have previously demonstrated the potential of CLE for diagnostic imaging of oral cavity lesions. To move toward real-time 3-D imaging, we interfaced an endomicroscope to an embedded computing system. The prototype system is capable of automated image acquisition and real-time volume rendering. Rendering results provide topographical and depth information. Our aim is to achieve a real-time 3-D fluorescence imaging system that can be used for diagnostic imaging and guided biopsy procedures of oral cavity lesions in a clinical setting. 2013-09-13T01:47:19Z 2019-12-06T20:02:11Z 2013-09-13T01:47:19Z 2019-12-06T20:02:11Z 2012 2012 Journal Article 1077-260X https://hdl.handle.net/10356/99001 http://hdl.handle.net/10220/13443 10.1109/JSTQE.2011.2177447 en IEEE journal of selected topics in quantum electronics © 2011 IEEE |
| spellingShingle | DRNTU::Engineering::Computer science and engineering Thong, Patricia Soo-Ping Olivo, Malini Tandjung, Stephanus Surijadarma Movania, Muhammad Mobeen Lin, Feng Qian, Kemao Seah, Hock Soon Soo, Khee-Chee Review of confocal fluorescence endomicroscopy for cancer detection |
| title | Review of confocal fluorescence endomicroscopy for cancer detection |
| title_full | Review of confocal fluorescence endomicroscopy for cancer detection |
| title_fullStr | Review of confocal fluorescence endomicroscopy for cancer detection |
| title_full_unstemmed | Review of confocal fluorescence endomicroscopy for cancer detection |
| title_short | Review of confocal fluorescence endomicroscopy for cancer detection |
| title_sort | review of confocal fluorescence endomicroscopy for cancer detection |
| topic | DRNTU::Engineering::Computer science and engineering |
| url | https://hdl.handle.net/10356/99001 http://hdl.handle.net/10220/13443 |
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