Mitosis-targeted anti-cancer therapies : where they stand
The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the hallmark of cancer revolves around cell-cycle deregulation, it is not surprising that antimitotic therapies are effecti...
| Main Authors: | , , |
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| Format: | Journal Article |
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2013
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| Online Access: | https://hdl.handle.net/10356/99097 http://hdl.handle.net/10220/12878 |
| _version_ | 1811683350875734016 |
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| author | Chan, K.-S. Li, H.-Y. Koh, Cheng Gee |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Chan, K.-S. Li, H.-Y. Koh, Cheng Gee |
| author_sort | Chan, K.-S. |
| collection | NTU |
| description | The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the hallmark of cancer revolves around cell-cycle deregulation, it is not surprising that antimitotic therapies are effective against the abnormal proliferation of transformed cells. Moreover, these antimitotic drugs are also highly selective and sensitive. Despite the robust rate of discovery and the development of mitosis-selective inhibitors, the unpredictable complexities of the human body’s response to these drugs still herald the biggest challenge towards clinical success. Undoubtedly, the need to bridge the gap between promising preclinical trials and effective translational bedside treatment prompts further investigations towards mapping out the mechanistic pathways of MCD, understanding how these drugs work as medicine in the body and more comprehensive target validations. In this review, current antimitotic agents are summarized with particular emphasis on the evaluation of their clinical efficacy as well as their limitations. In addition, we discuss the basis behind the lack of activity of these inhibitors in human trials and the potential and future directions of mitotic anticancer strategies. |
| first_indexed | 2024-10-01T04:11:21Z |
| format | Journal Article |
| id | ntu-10356/99097 |
| institution | Nanyang Technological University |
| last_indexed | 2024-10-01T04:11:21Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/990972022-06-07T00:25:32Z Mitosis-targeted anti-cancer therapies : where they stand Chan, K.-S. Li, H.-Y. Koh, Cheng Gee School of Biological Sciences DRNTU::Science::Biological sciences The strategy of clinically targeting cancerous cells at their most vulnerable state during mitosis has instigated numerous studies into the mitotic cell death (MCD) pathway. As the hallmark of cancer revolves around cell-cycle deregulation, it is not surprising that antimitotic therapies are effective against the abnormal proliferation of transformed cells. Moreover, these antimitotic drugs are also highly selective and sensitive. Despite the robust rate of discovery and the development of mitosis-selective inhibitors, the unpredictable complexities of the human body’s response to these drugs still herald the biggest challenge towards clinical success. Undoubtedly, the need to bridge the gap between promising preclinical trials and effective translational bedside treatment prompts further investigations towards mapping out the mechanistic pathways of MCD, understanding how these drugs work as medicine in the body and more comprehensive target validations. In this review, current antimitotic agents are summarized with particular emphasis on the evaluation of their clinical efficacy as well as their limitations. In addition, we discuss the basis behind the lack of activity of these inhibitors in human trials and the potential and future directions of mitotic anticancer strategies. 2013-08-02T04:17:18Z 2019-12-06T20:03:21Z 2013-08-02T04:17:18Z 2019-12-06T20:03:21Z 2012 2012 Journal Article Chan, K. S., Koh, C. G., & Li, H. Y. (2012). Mitosis-targeted anti-cancer therapies: where they stand. Cell death and disease, 3(10). 2041-4889 https://hdl.handle.net/10356/99097 http://hdl.handle.net/10220/12878 10.1038/cddis.2012.148 23076219 Cell death and disease |
| spellingShingle | DRNTU::Science::Biological sciences Chan, K.-S. Li, H.-Y. Koh, Cheng Gee Mitosis-targeted anti-cancer therapies : where they stand |
| title | Mitosis-targeted anti-cancer therapies : where they stand |
| title_full | Mitosis-targeted anti-cancer therapies : where they stand |
| title_fullStr | Mitosis-targeted anti-cancer therapies : where they stand |
| title_full_unstemmed | Mitosis-targeted anti-cancer therapies : where they stand |
| title_short | Mitosis-targeted anti-cancer therapies : where they stand |
| title_sort | mitosis targeted anti cancer therapies where they stand |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/99097 http://hdl.handle.net/10220/12878 |
| work_keys_str_mv | AT chanks mitosistargetedanticancertherapieswheretheystand AT lihy mitosistargetedanticancertherapieswheretheystand AT kohchenggee mitosistargetedanticancertherapieswheretheystand |