Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity
The aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO2) particles could influence both cytotoxicity and phototoxicity. TiO2 particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence a...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/99572 http://hdl.handle.net/10220/17450 |
| _version_ | 1826113703471218688 |
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| author | Xiong, Sijing Tang, Yuxin Ng, Huiyun Sheena Zhao, Xinxin Jiang, Zhelong Chen, Zhong Ng, Kee Woei Loo, Say Chye Joachim |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Xiong, Sijing Tang, Yuxin Ng, Huiyun Sheena Zhao, Xinxin Jiang, Zhelong Chen, Zhong Ng, Kee Woei Loo, Say Chye Joachim |
| author_sort | Xiong, Sijing |
| collection | NTU |
| description | The aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO2) particles could influence both cytotoxicity and phototoxicity. TiO2 particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence and presence of UV light. From the results, TiO2 particles with larger specific surface area were found to induce higher cyto- (UV absent) and photo-toxicity (UV activated) to cells after 24 h incubation. The observed cytotoxicity from TiO2 particles with larger surface area could be explained from their interactions with biomolecules. Upon photoactivation, a larger number of hydroxyl radicals were detected from TiO2 particles with larger surface area, again suggesting a surface area dependent phototoxic effect. On the other hand, pre-adsorbing TiO2 particles with extracellular proteins were found to decrease toxicity effects. |
| first_indexed | 2024-10-01T03:27:34Z |
| format | Journal Article |
| id | ntu-10356/99572 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:27:34Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/995722023-07-14T15:54:47Z Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity Xiong, Sijing Tang, Yuxin Ng, Huiyun Sheena Zhao, Xinxin Jiang, Zhelong Chen, Zhong Ng, Kee Woei Loo, Say Chye Joachim School of Materials Science & Engineering DRNTU::Engineering::Materials The aim of this study is to examine how different specific surface areas of similar-sized titanium dioxide (TiO2) particles could influence both cytotoxicity and phototoxicity. TiO2 particles of different specific surface areas were compared for their toxic effects on RAW264.7 cells in the absence and presence of UV light. From the results, TiO2 particles with larger specific surface area were found to induce higher cyto- (UV absent) and photo-toxicity (UV activated) to cells after 24 h incubation. The observed cytotoxicity from TiO2 particles with larger surface area could be explained from their interactions with biomolecules. Upon photoactivation, a larger number of hydroxyl radicals were detected from TiO2 particles with larger surface area, again suggesting a surface area dependent phototoxic effect. On the other hand, pre-adsorbing TiO2 particles with extracellular proteins were found to decrease toxicity effects. Accepted version 2013-11-08T04:56:15Z 2019-12-06T20:09:07Z 2013-11-08T04:56:15Z 2019-12-06T20:09:07Z 2013 2013 Journal Article Xiong, S., Tang, Y., Ng, H. S., Zhao, X., Jiang, Z., Chen, Z., Ng, K. W., & Loo, S. C. J. (2013). Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity. Toxicology, 304(8), 132-140. 0300-483X https://hdl.handle.net/10356/99572 http://hdl.handle.net/10220/17450 10.1016/j.tox.2012.12.015 en Toxicology © 2013 Elsevier Ireland Ltd. This is the author created version of a work that has been peer reviewed and accepted for publication by Toxicology, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.tox.2012.12.015]. application/pdf |
| spellingShingle | DRNTU::Engineering::Materials Xiong, Sijing Tang, Yuxin Ng, Huiyun Sheena Zhao, Xinxin Jiang, Zhelong Chen, Zhong Ng, Kee Woei Loo, Say Chye Joachim Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity |
| title | Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity |
| title_full | Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity |
| title_fullStr | Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity |
| title_full_unstemmed | Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity |
| title_short | Specific surface area of titanium dioxide (TiO2) particles influences cyto- and photo-toxicity |
| title_sort | specific surface area of titanium dioxide tio2 particles influences cyto and photo toxicity |
| topic | DRNTU::Engineering::Materials |
| url | https://hdl.handle.net/10356/99572 http://hdl.handle.net/10220/17450 |
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