Neuronal p60TRP expression modulates cardiac capacity
Heart failure, including myocardial infarction, is the leading cause for death and the incidence of cardiovascular diseases is predicted to continue to rise worldwide. In the present study we investigated the whole heart proteome profile of transgenic p60-Transcription Regulator Protein (p60TRP) mic...
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| Інші автори: | |
| Формат: | Journal Article |
| Мова: | English |
| Опубліковано: |
2013
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| Онлайн доступ: | https://hdl.handle.net/10356/99624 http://hdl.handle.net/10220/13718 |
| _version_ | 1826124053088305152 |
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| author | Mishra, Manisha Manavalan, Arulmani Sze, Siu Kwan Heese, Klaus |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Mishra, Manisha Manavalan, Arulmani Sze, Siu Kwan Heese, Klaus |
| author_sort | Mishra, Manisha |
| collection | NTU |
| description | Heart failure, including myocardial infarction, is the leading cause for death and the incidence of cardiovascular diseases is predicted to continue to rise worldwide. In the present study we investigated the whole heart proteome profile of transgenic p60-Transcription Regulator Protein (p60TRP) mice to gain an insight into the molecular events caused by the long-term effect of neural p60TRP over-expression on cardiac proteome changes and its potential implication for cardiovascular functions. Using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach, we identified 1148 proteins, out of which 116 were found to be significantly altered in the heart of neural transgenic p60TRP mice. Based on the observed data, we conclude that in vivo neural over-expression of transgenic p60TRP with its neuroprotective therapeutic potential significantly affects cardiovascular capacities. |
| first_indexed | 2024-10-01T06:14:22Z |
| format | Journal Article |
| id | ntu-10356/99624 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:14:22Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/996242020-03-07T12:18:20Z Neuronal p60TRP expression modulates cardiac capacity Mishra, Manisha Manavalan, Arulmani Sze, Siu Kwan Heese, Klaus School of Biological Sciences Institute of Advanced Studies DRNTU::Science::Biological sciences Heart failure, including myocardial infarction, is the leading cause for death and the incidence of cardiovascular diseases is predicted to continue to rise worldwide. In the present study we investigated the whole heart proteome profile of transgenic p60-Transcription Regulator Protein (p60TRP) mice to gain an insight into the molecular events caused by the long-term effect of neural p60TRP over-expression on cardiac proteome changes and its potential implication for cardiovascular functions. Using an iTRAQ (isobaric tags for relative and absolute quantitation)-based proteomics research approach, we identified 1148 proteins, out of which 116 were found to be significantly altered in the heart of neural transgenic p60TRP mice. Based on the observed data, we conclude that in vivo neural over-expression of transgenic p60TRP with its neuroprotective therapeutic potential significantly affects cardiovascular capacities. 2013-09-30T03:39:39Z 2019-12-06T20:09:36Z 2013-09-30T03:39:39Z 2019-12-06T20:09:36Z 2011 2011 Journal Article Mishra, M., Manavalan, A., Sze, S. K., & Heese, K. (2011). Neuronal p60TRP expression modulates cardiac capacity. Journal of proteomics, 75(5), 1600-1617. https://hdl.handle.net/10356/99624 http://hdl.handle.net/10220/13718 10.1016/j.jprot.2011.11.034 en Journal of proteomics |
| spellingShingle | DRNTU::Science::Biological sciences Mishra, Manisha Manavalan, Arulmani Sze, Siu Kwan Heese, Klaus Neuronal p60TRP expression modulates cardiac capacity |
| title | Neuronal p60TRP expression modulates cardiac capacity |
| title_full | Neuronal p60TRP expression modulates cardiac capacity |
| title_fullStr | Neuronal p60TRP expression modulates cardiac capacity |
| title_full_unstemmed | Neuronal p60TRP expression modulates cardiac capacity |
| title_short | Neuronal p60TRP expression modulates cardiac capacity |
| title_sort | neuronal p60trp expression modulates cardiac capacity |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/99624 http://hdl.handle.net/10220/13718 |
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