In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt
Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO2) in a simulated in vitro cornea inflam...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/99628 http://hdl.handle.net/10220/13735 |
| _version_ | 1824455813315428352 |
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| author | Tan, Anna C. S. Beuerman, Roger W. Mehta, Jodhbir S. Tan, Xiao Wei Riau, Andri Shi, Zhi Long Neoh, Koon Gee Khor, Khiam Aik Tan, Donald |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Tan, Anna C. S. Beuerman, Roger W. Mehta, Jodhbir S. Tan, Xiao Wei Riau, Andri Shi, Zhi Long Neoh, Koon Gee Khor, Khiam Aik Tan, Donald |
| author_sort | Tan, Anna C. S. |
| collection | NTU |
| description | Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO2) in a simulated in vitro cornea inflammation environment.
Lipopolysaccharide-stimulated cytokine secretions were evaluated with human corneal fibroblasts on both HA and TiO2. Material specimens were subjected to electrochemical and long-term incubation test with artificial tear fluid (ATF) of various acidities. Topography and surface roughness of material discs were analysed by scanning electron microscopy and atomic force microscopy.
There were less cytokines secreted from human corneal fibroblasts seeded on TiO2 substrates as compared with HA. TiO2 was more resistant to the corrosion effect caused by acidic ATF in contrast to HA. Moreover, the elemental composition of TiO2 was more stable than HA after long-term incubation with ATF.
TiO2 is more resistant to inflammatory degradation and has a higher corrosion resistance as compared with HA, and in this regard may be a suitable material to replace HA as an osteo-odonto-keratoprosthesis skirt. This would reduce resorption rates for KPro surgery. |
| first_indexed | 2025-02-19T03:44:10Z |
| format | Journal Article |
| id | ntu-10356/99628 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:44:10Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/996282022-02-16T16:26:45Z In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt Tan, Anna C. S. Beuerman, Roger W. Mehta, Jodhbir S. Tan, Xiao Wei Riau, Andri Shi, Zhi Long Neoh, Koon Gee Khor, Khiam Aik Tan, Donald School of Mechanical and Aerospace Engineering DRNTU::Engineering::Mechanical engineering Keratoprosthesis (KPro) devices are prone to long-term corrosion and microbiological assault. The authors aimed to compare the inflammatory response and material dissolution properties of two candidate KPro skirt materials, hydroxyapatite (HA) and titania (TiO2) in a simulated in vitro cornea inflammation environment. Lipopolysaccharide-stimulated cytokine secretions were evaluated with human corneal fibroblasts on both HA and TiO2. Material specimens were subjected to electrochemical and long-term incubation test with artificial tear fluid (ATF) of various acidities. Topography and surface roughness of material discs were analysed by scanning electron microscopy and atomic force microscopy. There were less cytokines secreted from human corneal fibroblasts seeded on TiO2 substrates as compared with HA. TiO2 was more resistant to the corrosion effect caused by acidic ATF in contrast to HA. Moreover, the elemental composition of TiO2 was more stable than HA after long-term incubation with ATF. TiO2 is more resistant to inflammatory degradation and has a higher corrosion resistance as compared with HA, and in this regard may be a suitable material to replace HA as an osteo-odonto-keratoprosthesis skirt. This would reduce resorption rates for KPro surgery. 2013-09-30T06:43:41Z 2019-12-06T20:09:38Z 2013-09-30T06:43:41Z 2019-12-06T20:09:38Z 2012 2012 Journal Article Tan, X. W., Riau, A., Shi, Z. L., Tan, A. C. S., Neoh, K. G., Khor, K. A., Beuerman, R. W., Tan, D., & Mehta, J. S. (2012). In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt. British journal of ophthalmology, 96(9), 1252-1258. https://hdl.handle.net/10356/99628 http://hdl.handle.net/10220/13735 10.1136/bjophthalmol-2012-301633 22802307 en British journal of ophthalmology |
| spellingShingle | DRNTU::Engineering::Mechanical engineering Tan, Anna C. S. Beuerman, Roger W. Mehta, Jodhbir S. Tan, Xiao Wei Riau, Andri Shi, Zhi Long Neoh, Koon Gee Khor, Khiam Aik Tan, Donald In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt |
| title | In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt |
| title_full | In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt |
| title_fullStr | In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt |
| title_full_unstemmed | In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt |
| title_short | In vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt |
| title_sort | in vitro effect of a corrosive hostile ocular surface on candidate biomaterials for keratoprosthesis skirt |
| topic | DRNTU::Engineering::Mechanical engineering |
| url | https://hdl.handle.net/10356/99628 http://hdl.handle.net/10220/13735 |
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