A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex
A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabil...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/99688 http://hdl.handle.net/10220/9988 |
| _version_ | 1826122030902149120 |
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| author | Wang, Jintao Lu, Kaihui Xuan, Shuguang Toh, Zaozhen Zhang, Dawei Shao, Fangwei |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Wang, Jintao Lu, Kaihui Xuan, Shuguang Toh, Zaozhen Zhang, Dawei Shao, Fangwei |
| author_sort | Wang, Jintao |
| collection | NTU |
| description | A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ. |
| first_indexed | 2024-10-01T05:41:50Z |
| format | Journal Article |
| id | ntu-10356/99688 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:41:50Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/996882023-02-28T19:41:39Z A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex Wang, Jintao Lu, Kaihui Xuan, Shuguang Toh, Zaozhen Zhang, Dawei Shao, Fangwei School of Physical and Mathematical Sciences DRNTU::Science::Mathematics A new G-quadruplex (GQ) stabilizer, [Pt(Dip)2](PF6)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), is prepared by the microwave irradiation method. The complex can highly stabilize G-quadruplex, but has negligible interactions with duplex DNA. Aromatic anchors on the polypyridyl ligands bestow the stabilizer with a high binding preference towards parallel GQ. Accepted version 2013-05-27T01:03:08Z 2019-12-06T20:10:21Z 2013-05-27T01:03:08Z 2019-12-06T20:10:21Z 2013 2013 Journal Article Wang, J., Lu K., Xuan, S., Toh, Z., Zhang, D., & Shao F. (2013). A Pt(II)-Dip complex stabilizes parallel c-myc G-quadruplex. Chemical Communications, 49(42), 4758-4760. https://hdl.handle.net/10356/99688 http://hdl.handle.net/10220/9988 10.1039/c3cc40868j en Chemical communications © 2013 The Royal Society of Chemistry This is the author created version of a work that has been peer reviewed and accepted for publication by Chemical Communications, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/c3cc40868j]. application/pdf |
| spellingShingle | DRNTU::Science::Mathematics Wang, Jintao Lu, Kaihui Xuan, Shuguang Toh, Zaozhen Zhang, Dawei Shao, Fangwei A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex |
| title | A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex |
| title_full | A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex |
| title_fullStr | A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex |
| title_full_unstemmed | A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex |
| title_short | A Pt(II)-dip complex stabilizes parallel c-myc G-quadruplex |
| title_sort | pt ii dip complex stabilizes parallel c myc g quadruplex |
| topic | DRNTU::Science::Mathematics |
| url | https://hdl.handle.net/10356/99688 http://hdl.handle.net/10220/9988 |
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