Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase
Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-...
| Main Authors: | , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/99731 http://hdl.handle.net/10220/17528 |
| _version_ | 1811690227512639488 |
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| author | Rice, Scott A. Kardak, Bharat G. Kelso, Michael J. Yepuri, Nageshwar Rao Barraud, Nicolas Mohammadi, Nasim Shah Kjelleberg, Staffan |
| author_facet | Rice, Scott A. Kardak, Bharat G. Kelso, Michael J. Yepuri, Nageshwar Rao Barraud, Nicolas Mohammadi, Nasim Shah Kjelleberg, Staffan |
| author_sort | Rice, Scott A. |
| collection | NTU |
| description | Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. |
| first_indexed | 2024-10-01T06:00:39Z |
| format | Journal Article |
| id | ntu-10356/99731 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:00:39Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/997312020-03-07T12:47:10Z Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase Rice, Scott A. Kardak, Bharat G. Kelso, Michael J. Yepuri, Nageshwar Rao Barraud, Nicolas Mohammadi, Nasim Shah Kjelleberg, Staffan Biofilms Use of biofilm dispersing NO-donor compounds in combination with antibiotics has emerged as a promising new strategy for treating drug-resistant bacterial biofilm infections. This paper details the synthesis and preliminary evaluation of six cephalosporin-3′-diazeniumdiolates as biofilm-targeted NO-donor prodrugs. Each of the compounds is shown to selectively release NO following reaction with the bacteria-specific enzyme β-lactamase and to trigger dispersion of Pseudomonas aeruginosa biofilms in vitro. 2013-11-08T07:50:29Z 2019-12-06T20:10:49Z 2013-11-08T07:50:29Z 2019-12-06T20:10:49Z 2013 2013 Journal Article Yepuri, N. R., Barraud, N., Mohammadi, N. S., Kardak, B. G., Kjelleberg, S., Rice, S. A., et al. (2013). Synthesis of cephalosporin-3′-diazeniumdiolates: biofilm dispersing NO-donor prodrugs activated by β-lactamase. Chemical communications, 49(42), 4791-4793. https://hdl.handle.net/10356/99731 http://hdl.handle.net/10220/17528 10.1039/c3cc40869h en Chemical communications |
| spellingShingle | Biofilms Rice, Scott A. Kardak, Bharat G. Kelso, Michael J. Yepuri, Nageshwar Rao Barraud, Nicolas Mohammadi, Nasim Shah Kjelleberg, Staffan Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase |
| title | Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase |
| title_full | Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase |
| title_fullStr | Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase |
| title_full_unstemmed | Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase |
| title_short | Synthesis of cephalosporin-3′-diazeniumdiolates : biofilm dispersing NO-donor prodrugs activated by β-lactamase |
| title_sort | synthesis of cephalosporin 3 diazeniumdiolates biofilm dispersing no donor prodrugs activated by β lactamase |
| topic | Biofilms |
| url | https://hdl.handle.net/10356/99731 http://hdl.handle.net/10220/17528 |
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