Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging
In this contribution, we show that Au NRs functionalized with PEG molecules can be used as absorption nanoprobes for near-infrared imaging in live animals. We have found that the contrast signal of the in vivo image is dependent upon the transmission ability of the NIR light interacting with the dif...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/99775 http://hdl.handle.net/10220/17780 |
| _version_ | 1826116239251996672 |
|---|---|
| author | Zhu, Jing Gong, Tianxun Kopwitthaya, Atcha Hu, Rui Law, Wing-Cheung Roy, Indrajit Huang, Huijie Yong, Ken-Tye |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Zhu, Jing Gong, Tianxun Kopwitthaya, Atcha Hu, Rui Law, Wing-Cheung Roy, Indrajit Huang, Huijie Yong, Ken-Tye |
| author_sort | Zhu, Jing |
| collection | NTU |
| description | In this contribution, we show that Au NRs functionalized with PEG molecules can be used as absorption nanoprobes for near-infrared imaging in live animals. We have found that the contrast signal of the in vivo image is dependent upon the transmission ability of the NIR light interacting with the different aspect ratios of Au NRs. Our study was focused on absorption in vivo imaging at 700 nm, which is within the transmission window of the skin. NIR absorption in vivo imaging was carried out by subcutaneous injection of mice with PEGylated Au NRs that have a LSPR around 700 nm. The formulation showed strong contrast signals under the tissues upon irradiation with NIR light. More importantly, our theoretical calculation suggested that the high contrast signals from the PEGylated Au NRs were generated via the NIR light absorption of the Au NRs within the tissue. |
| first_indexed | 2024-10-01T04:08:04Z |
| format | Journal Article |
| id | ntu-10356/99775 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:08:04Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/997752020-03-07T14:00:31Z Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging Zhu, Jing Gong, Tianxun Kopwitthaya, Atcha Hu, Rui Law, Wing-Cheung Roy, Indrajit Huang, Huijie Yong, Ken-Tye School of Electrical and Electronic Engineering DRNTU::Engineering::Electrical and electronic engineering In this contribution, we show that Au NRs functionalized with PEG molecules can be used as absorption nanoprobes for near-infrared imaging in live animals. We have found that the contrast signal of the in vivo image is dependent upon the transmission ability of the NIR light interacting with the different aspect ratios of Au NRs. Our study was focused on absorption in vivo imaging at 700 nm, which is within the transmission window of the skin. NIR absorption in vivo imaging was carried out by subcutaneous injection of mice with PEGylated Au NRs that have a LSPR around 700 nm. The formulation showed strong contrast signals under the tissues upon irradiation with NIR light. More importantly, our theoretical calculation suggested that the high contrast signals from the PEGylated Au NRs were generated via the NIR light absorption of the Au NRs within the tissue. 2013-11-19T04:51:52Z 2019-12-06T20:11:18Z 2013-11-19T04:51:52Z 2019-12-06T20:11:18Z 2013 2013 Journal Article Zhu, J., Gong, T., Kopwitthaya, A., Hu, R., Law, W.-C., Roy, I., et al. (2013). Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging. RSC Advances, 3(30), 12280-12286. 2046-2069 https://hdl.handle.net/10356/99775 http://hdl.handle.net/10220/17780 10.1039/c3ra41777h en RSC advances |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering Zhu, Jing Gong, Tianxun Kopwitthaya, Atcha Hu, Rui Law, Wing-Cheung Roy, Indrajit Huang, Huijie Yong, Ken-Tye Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging |
| title | Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging |
| title_full | Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging |
| title_fullStr | Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging |
| title_full_unstemmed | Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging |
| title_short | Synthesis of PEGylated gold nanorods (Au NRs) as absorption nanoprobes for near-infrared optical imaging |
| title_sort | synthesis of pegylated gold nanorods au nrs as absorption nanoprobes for near infrared optical imaging |
| topic | DRNTU::Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/99775 http://hdl.handle.net/10220/17780 |
| work_keys_str_mv | AT zhujing synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging AT gongtianxun synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging AT kopwitthayaatcha synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging AT hurui synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging AT lawwingcheung synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging AT royindrajit synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging AT huanghuijie synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging AT yongkentye synthesisofpegylatedgoldnanorodsaunrsasabsorptionnanoprobesfornearinfraredopticalimaging |