Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein
A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provide...
| Main Authors: | , |
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| Format: | Journal Article |
| Language: | English |
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2013
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| Online Access: | https://hdl.handle.net/10356/99817 http://hdl.handle.net/10220/17769 |
| _version_ | 1811693930000941056 |
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| author | Petersen, Mette T. Nielsen, Thomas E. |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Petersen, Mette T. Nielsen, Thomas E. |
| author_sort | Petersen, Mette T. |
| collection | NTU |
| description | A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provided a new entry for the total synthesis of the antileukemic natural product violacein. |
| first_indexed | 2024-10-01T06:59:30Z |
| format | Journal Article |
| id | ntu-10356/99817 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:59:30Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/998172020-03-07T12:47:10Z Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein Petersen, Mette T. Nielsen, Thomas E. School of Biological Sciences DRNTU::Science::Biological sciences A series of 5-substituted 2-pyrrolidinones was synthesized through a one-pot ruthenium alkylidene-catalyzed tandem RCM/isomerization/nucleophilic addition sequence. The intermediates resulting from RCM/isomerization showed reactivity toward electrophiles in aldol condensation reactions which provided a new entry for the total synthesis of the antileukemic natural product violacein. 2013-11-19T04:00:21Z 2019-12-06T20:11:56Z 2013-11-19T04:00:21Z 2019-12-06T20:11:56Z 2013 2013 Journal Article Petersen, M. T., & Nielsen, T. E. (2013). Tandem Ring-Closing Metathesis/Isomerization Reactions for the Total Synthesis of Violacein. Organic Letters, 15(8), 1986-1989. https://hdl.handle.net/10356/99817 http://hdl.handle.net/10220/17769 10.1021/ol400654r en Organic letters |
| spellingShingle | DRNTU::Science::Biological sciences Petersen, Mette T. Nielsen, Thomas E. Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title | Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_full | Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_fullStr | Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_full_unstemmed | Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_short | Tandem ring-closing metathesis/isomerization reactions for the total synthesis of violacein |
| title_sort | tandem ring closing metathesis isomerization reactions for the total synthesis of violacein |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/99817 http://hdl.handle.net/10220/17769 |
| work_keys_str_mv | AT petersenmettet tandemringclosingmetathesisisomerizationreactionsforthetotalsynthesisofviolacein AT nielsenthomase tandemringclosingmetathesisisomerizationreactionsforthetotalsynthesisofviolacein |