Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo
Engineering multifunctional nanocarriers for targeted drug delivery shows promising potentials to revolutionize the cancer chemotherapy. Simple methods to optimize physicochemical characteristics and surface composition of the drug nanocarriers need to be developed in order to tackle major challenge...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2014
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| Online Access: | https://hdl.handle.net/10356/99927 http://hdl.handle.net/10220/19650 |
| _version_ | 1826124758837624832 |
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| author | Zhang, Quan Wang, Xiaoling Li, Pei-Zhou Nguyen, Kim Truc Wang, Xiao-Jun Luo, Zhong Zhang, Huacheng Tan, Nguan Soon Zhao, Yanli |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Zhang, Quan Wang, Xiaoling Li, Pei-Zhou Nguyen, Kim Truc Wang, Xiao-Jun Luo, Zhong Zhang, Huacheng Tan, Nguan Soon Zhao, Yanli |
| author_sort | Zhang, Quan |
| collection | NTU |
| description | Engineering multifunctional nanocarriers for targeted drug delivery shows promising potentials to revolutionize the cancer chemotherapy. Simple methods to optimize physicochemical characteristics and surface composition of the drug nanocarriers need to be developed in order to tackle major challenges for smooth translation of suitable nanocarriers to clinical applications. Here, rational development and utilization of multifunctional mesoporous silica nanoparticles (MSNPs) for targeting MDA-MB-231 xenograft model breast cancer in vivo are reported. Uniform and redispersible poly(ethylene glycol)-incorporated MSNPs with three different sizes (48, 72, 100 nm) are synthesized. They are then functionalized with amino-β-cyclodextrin bridged by cleavable disulfide bonds, where amino-β-cyclodextrin blocks drugs inside the mesopores. The incorporation of active folate targeting ligand onto 48 nm of multifunctional MSNPs (PEG-MSNPs48-CD-PEG-FA) leads to improved and selective uptake of the nanoparticles into tumor. Targeted drug delivery capability of PEG-MSNPs48-CD-PEG-FA is demonstrated by significant inhibition of the tumor growth in mice treated with doxorubicin-loaded nanoparticles, where doxorubicin is released triggered by intracellular acidic pH and glutathione. Doxorubicin-loaded PEG-MSNPs48-CD-PEG-FA exhibits better in vivo therapeutic efficacy as compared with free doxorubicin and non-targeted nanoparticles. Current study presents successful utilization of multifunctional MSNP-based drug nanocarriers for targeted cancer therapy in vivo. |
| first_indexed | 2024-10-01T06:25:37Z |
| format | Journal Article |
| id | ntu-10356/99927 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:25:37Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | ntu-10356/999272020-06-01T10:01:36Z Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo Zhang, Quan Wang, Xiaoling Li, Pei-Zhou Nguyen, Kim Truc Wang, Xiao-Jun Luo, Zhong Zhang, Huacheng Tan, Nguan Soon Zhao, Yanli School of Materials Science & Engineering School of Biological Sciences School of Physical and Mathematical Sciences DRNTU::Engineering::Materials::Nanostructured materials DRNTU::Science::Medicine Engineering multifunctional nanocarriers for targeted drug delivery shows promising potentials to revolutionize the cancer chemotherapy. Simple methods to optimize physicochemical characteristics and surface composition of the drug nanocarriers need to be developed in order to tackle major challenges for smooth translation of suitable nanocarriers to clinical applications. Here, rational development and utilization of multifunctional mesoporous silica nanoparticles (MSNPs) for targeting MDA-MB-231 xenograft model breast cancer in vivo are reported. Uniform and redispersible poly(ethylene glycol)-incorporated MSNPs with three different sizes (48, 72, 100 nm) are synthesized. They are then functionalized with amino-β-cyclodextrin bridged by cleavable disulfide bonds, where amino-β-cyclodextrin blocks drugs inside the mesopores. The incorporation of active folate targeting ligand onto 48 nm of multifunctional MSNPs (PEG-MSNPs48-CD-PEG-FA) leads to improved and selective uptake of the nanoparticles into tumor. Targeted drug delivery capability of PEG-MSNPs48-CD-PEG-FA is demonstrated by significant inhibition of the tumor growth in mice treated with doxorubicin-loaded nanoparticles, where doxorubicin is released triggered by intracellular acidic pH and glutathione. Doxorubicin-loaded PEG-MSNPs48-CD-PEG-FA exhibits better in vivo therapeutic efficacy as compared with free doxorubicin and non-targeted nanoparticles. Current study presents successful utilization of multifunctional MSNP-based drug nanocarriers for targeted cancer therapy in vivo. 2014-06-11T03:31:47Z 2019-12-06T20:13:43Z 2014-06-11T03:31:47Z 2019-12-06T20:13:43Z 2013 2013 Journal Article Zhang, Q., Wang, X., Li, P.-Z., Nguyen, K. T., Wang, X.-J., Luo, Z., et al. (2014). Biocompatible, Uniform, and Redispersible Mesoporous Silica Nanoparticles for Cancer-Targeted Drug Delivery In Vivo. Advanced Functional Materials, 24(17), 2450-2461. 1616-301X https://hdl.handle.net/10356/99927 http://hdl.handle.net/10220/19650 10.1002/adfm.201302988 en Advanced functional materials © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| spellingShingle | DRNTU::Engineering::Materials::Nanostructured materials DRNTU::Science::Medicine Zhang, Quan Wang, Xiaoling Li, Pei-Zhou Nguyen, Kim Truc Wang, Xiao-Jun Luo, Zhong Zhang, Huacheng Tan, Nguan Soon Zhao, Yanli Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo |
| title | Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo |
| title_full | Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo |
| title_fullStr | Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo |
| title_full_unstemmed | Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo |
| title_short | Biocompatible, uniform, and redispersible mesoporous silica nanoparticles for cancer-targeted drug delivery in vivo |
| title_sort | biocompatible uniform and redispersible mesoporous silica nanoparticles for cancer targeted drug delivery in vivo |
| topic | DRNTU::Engineering::Materials::Nanostructured materials DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/99927 http://hdl.handle.net/10220/19650 |
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