| Summary: | Type 2 diabetes mellitus is a chronic disease that often goes undiagnosed
and is not recognized by the patient and cause microvascular and macrovascular
complications that can be prevented with early treatment. Therefore we need a
diagnosis as early as possible with a valid and reliable diagnostic tool.
Hemoglobin A1c � 6.5% is one of the criteria for the diagnosis of type 2 diabetes
mellitus according to ADA 2010 and recommended by WHO in 2011. This assay
is more convenient, faster and requires no special preparation in comparison with
other diagnostic parameters, fasting blood glucose. From previous studies found
differences in HbA1c cutoff value in some populations that are likely to be
influenced by race and ethnicity. The purpose of this study was to test the
appearance of HbA1c diagnosis and determine the cutoff value of HbA1c for the
diagnosis of type 2 diabetes mellitus in a population with risk factors in the DIY
Province.
This study used a cross-sectional design and is a diagnostic test with
TTGO as gold standard. Subjects were resident in the district Gondokusuman,
Banguntapan and Condong Catur who have risk factors for type 2 diabetes
mellitus. Examination of HbA1c using HPLC method (Biorad D10). Sensitivity,
specificity, positive predictive value, negative predictive value, accuracy and
likelihood ratio was calculated with a 2x2 table. ROC curve analysis performed
using SPSS.
The study was conducted on 235 subjects. Examination of HbA1c by 6.3%
cutoff on individuals at high risk of type 2 diabetes mellitus is expected to provide
sensitivity and specificity of at least 90% for the diagnosis of type 2 diabetes
mellitus in Yogyakarta, so that management can be provided as early as possible
to prevent complications.
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