UJI DIAGNOSIS KRITERIA McISAAC PADA FARINGITIS AKUT STREPTOKOKUS β HEMOLITIKUS GRUP A
Early use of antibiotic in acute upper respiratory infections has become controversy because most are caused by viral infection. Appropriate strategy is needed todiagnoseacute pharyngitis so antibiotic usage will be more appropriate and reduce excessive antibiotic usage with all the consequences.Thi...
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| _version_ | 1826045707559108608 |
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| author | , Imanuel Yulius Malino , Prof. dr. Sri Suparyati Soenarto, PhD, Sp.A(K), |
| author_facet | , Imanuel Yulius Malino , Prof. dr. Sri Suparyati Soenarto, PhD, Sp.A(K), |
| author_sort | , Imanuel Yulius Malino |
| collection | UGM |
| description | Early use of antibiotic in acute upper respiratory infections has become
controversy because most are caused by viral infection. Appropriate strategy is
needed todiagnoseacute pharyngitis so antibiotic usage will be more appropriate
and reduce excessive antibiotic usage with all the consequences.This study aim to
do diagnostic test for McIsaacCriteria in diagnosing Group-A β-hemolytic
Streptococcus (GABHS) on children with acute pharyngitis. This was a crosssectional
study, diagnostic test of clinical criteria with throat swabsculture as the
gold standard. The research was conducted August 1
st
, 2011 until February 6
th
,
2012 on children 3-14 years oldatpediatric outpatient clinic and emergency wardat
Sanglah Public Hospital and pediatric outpatient clinic at WangayaHospital.
Five hundred and fifty cases with acute pharyngitis during the study
period, 313 of them 3-14 years old, 199 children were excluded due to history of
antibiotics in two weeks, 114 children who meet the inclusion and exclusion
criteria are involved. GABHS prevalence in this study are 7.9%. McIsaac�s Area
Under the Curve (AUC) from Receiver Operating Characteristic (ROC) curve is
78.1% with P = 0.005 (95% CI 60.3% to 96%). The optimal ROC cutoff for
McIsaacscoreis greater than or equal to 4 which has 66.7%(95% CI 49% to 97%)
of sensitivity, 87.6% (CI 95% 81% to 94%) of specificity, 31.6% (CI 95 % 11%
to 52%) of positive predictive value (PPV), 96.8% (95% CI 93% to 100%)of
negative predictive value (NPV),86.0%of accuracy, positive likelihood ratio
(LR+) is 5.4 (95% CI 2.7 to 10.7) and negative likelihood ratio (LR-) is 0.4 (95%
CI 0.2 to 0.9).
McIsaac Criteria total scoreofless than four is favorable to
exclude GABHS pharygitis diagnosis. Total score criteria McIsaac greter than or
equal to four requiresfurther examination toconfirm GABHS pharyngitis. |
| first_indexed | 2024-03-13T22:41:32Z |
| format | Thesis |
| id | oai:generic.eprints.org:100123 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:41:32Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1001232016-03-04T08:47:10Z https://repository.ugm.ac.id/100123/ UJI DIAGNOSIS KRITERIA McISAAC PADA FARINGITIS AKUT STREPTOKOKUS β HEMOLITIKUS GRUP A , Imanuel Yulius Malino , Prof. dr. Sri Suparyati Soenarto, PhD, Sp.A(K), ETD Early use of antibiotic in acute upper respiratory infections has become controversy because most are caused by viral infection. Appropriate strategy is needed todiagnoseacute pharyngitis so antibiotic usage will be more appropriate and reduce excessive antibiotic usage with all the consequences.This study aim to do diagnostic test for McIsaacCriteria in diagnosing Group-A β-hemolytic Streptococcus (GABHS) on children with acute pharyngitis. This was a crosssectional study, diagnostic test of clinical criteria with throat swabsculture as the gold standard. The research was conducted August 1 st , 2011 until February 6 th , 2012 on children 3-14 years oldatpediatric outpatient clinic and emergency wardat Sanglah Public Hospital and pediatric outpatient clinic at WangayaHospital. Five hundred and fifty cases with acute pharyngitis during the study period, 313 of them 3-14 years old, 199 children were excluded due to history of antibiotics in two weeks, 114 children who meet the inclusion and exclusion criteria are involved. GABHS prevalence in this study are 7.9%. McIsaac�s Area Under the Curve (AUC) from Receiver Operating Characteristic (ROC) curve is 78.1% with P = 0.005 (95% CI 60.3% to 96%). The optimal ROC cutoff for McIsaacscoreis greater than or equal to 4 which has 66.7%(95% CI 49% to 97%) of sensitivity, 87.6% (CI 95% 81% to 94%) of specificity, 31.6% (CI 95 % 11% to 52%) of positive predictive value (PPV), 96.8% (95% CI 93% to 100%)of negative predictive value (NPV),86.0%of accuracy, positive likelihood ratio (LR+) is 5.4 (95% CI 2.7 to 10.7) and negative likelihood ratio (LR-) is 0.4 (95% CI 0.2 to 0.9). McIsaac Criteria total scoreofless than four is favorable to exclude GABHS pharygitis diagnosis. Total score criteria McIsaac greter than or equal to four requiresfurther examination toconfirm GABHS pharyngitis. [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , Imanuel Yulius Malino and , Prof. dr. Sri Suparyati Soenarto, PhD, Sp.A(K), (2012) UJI DIAGNOSIS KRITERIA McISAAC PADA FARINGITIS AKUT STREPTOKOKUS β HEMOLITIKUS GRUP A. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56387 |
| spellingShingle | ETD , Imanuel Yulius Malino , Prof. dr. Sri Suparyati Soenarto, PhD, Sp.A(K), UJI DIAGNOSIS KRITERIA McISAAC PADA FARINGITIS AKUT STREPTOKOKUS β HEMOLITIKUS GRUP A |
| title | UJI DIAGNOSIS KRITERIA McISAAC
PADA FARINGITIS AKUT
STREPTOKOKUS β HEMOLITIKUS GRUP A |
| title_full | UJI DIAGNOSIS KRITERIA McISAAC
PADA FARINGITIS AKUT
STREPTOKOKUS β HEMOLITIKUS GRUP A |
| title_fullStr | UJI DIAGNOSIS KRITERIA McISAAC
PADA FARINGITIS AKUT
STREPTOKOKUS β HEMOLITIKUS GRUP A |
| title_full_unstemmed | UJI DIAGNOSIS KRITERIA McISAAC
PADA FARINGITIS AKUT
STREPTOKOKUS β HEMOLITIKUS GRUP A |
| title_short | UJI DIAGNOSIS KRITERIA McISAAC
PADA FARINGITIS AKUT
STREPTOKOKUS β HEMOLITIKUS GRUP A |
| title_sort | uji diagnosis kriteria mcisaac pada faringitis akut streptokokus i² hemolitikus grup a |
| topic | ETD |
| work_keys_str_mv | AT imanuelyuliusmalino ujidiagnosiskriteriamcisaacpadafaringitisakutstreptokokusi2hemolitikusgrupa AT profdrsrisuparyatisoenartophdspak ujidiagnosiskriteriamcisaacpadafaringitisakutstreptokokusi2hemolitikusgrupa |