PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI STADIUM LANJUT
Background: For the treatment of advanced carcinoma of the cervix uteri chemoradiation protocol performed weekly or three weekly. To determine the therapeutic response comparison of both protocols, need to check the tumor marker SCC antigen before and after chemotherapy. Purpose: To determine the ra...
| Main Authors: | , |
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| _version_ | 1797032654424506368 |
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| author | , Milhan , Prof. Dr. dr. Ibnu Pranoto, SpAnd, SpOG(K) |
| author_facet | , Milhan , Prof. Dr. dr. Ibnu Pranoto, SpAnd, SpOG(K) |
| author_sort | , Milhan |
| collection | UGM |
| description | Background: For the treatment of advanced carcinoma of the cervix uteri
chemoradiation protocol performed weekly or three weekly. To determine the therapeutic
response comparison of both protocols, need to check the tumor marker SCC antigen
before and after chemotherapy.
Purpose: To determine the ratio of SCC antigen changes before and after the third on
the protocol of chemotherapy weekly and three weekly protocol at an advanced
carcinoma of the cervix uteri.
Methods: The study was performed in RS Sardjito, study subjects were patients with
advanced carcinoma of cervix uteri who received chemotherapy protocol weekly or three
weekly. Examination of SCC antigen levels before and after the third chemotherapy.
Results: There were 30 cases, each of the 15 cases who received weekly protocol and
the protocol of three weekly 15 cases. Most 46-55 years old (60.0%) in the weekly
protocol and also 60.0% at three weekly protocol. Parity 3 or more, 73.3% and 66.7%.
Elementary education level (33.3% and 73.3%). Class III of ward (73.3% and 66.7%).
Histopathology of epidermoid carcinoma (40.0%) and squamous cell carcinoma (40.0%).
Stage IIB (73.3%) and IIIA (40.0%). At the weekly protocol, the average (mean) SCC
antigen levels before treatment (SCC Pre Ag) 8.080 ± 13.151 mg / L and SCC antigen
after the weekly protocol (SCC Post Ag) 3.067 ± 3.465 mg / L, with changes (decreased
levels) amounting to 5.013 ± 12.000 mg / L. While the protocol three weekly average SCC
Pre Ag ± 17.610 21.575 ug / L and Post SCC Ag is 8.074 ± 14.760 mg / L, with changes
(decreased levels) for 9.536 ± 14.873 mg / L. With a paired t test individually on a weekly
and three weekly protocol obtained: First, there is no change in a significant SCC antigen
levels before and after the third on the protocol of chemotherapy weekly. Second, there is
a change in a significant SCC antigen levels before and after the third chemotherapy at
three weekly protocol. Test done together with the independent t test acquired
conclusions: there is no change in a significant SCC antigen levels before and after the
third chemotherapy between the weekly protocol and three weekly protocols.
Conclusion: there is no change in a significant SCC antigen levels before and after the
third chemotherapy between the weekly protocol and three weekly protocols on advanced
carcinoma of the cervix uteri. |
| first_indexed | 2024-03-13T22:41:39Z |
| format | Thesis |
| id | oai:generic.eprints.org:100163 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:41:39Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1001632016-03-04T08:47:48Z https://repository.ugm.ac.id/100163/ PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI STADIUM LANJUT , Milhan , Prof. Dr. dr. Ibnu Pranoto, SpAnd, SpOG(K) ETD Background: For the treatment of advanced carcinoma of the cervix uteri chemoradiation protocol performed weekly or three weekly. To determine the therapeutic response comparison of both protocols, need to check the tumor marker SCC antigen before and after chemotherapy. Purpose: To determine the ratio of SCC antigen changes before and after the third on the protocol of chemotherapy weekly and three weekly protocol at an advanced carcinoma of the cervix uteri. Methods: The study was performed in RS Sardjito, study subjects were patients with advanced carcinoma of cervix uteri who received chemotherapy protocol weekly or three weekly. Examination of SCC antigen levels before and after the third chemotherapy. Results: There were 30 cases, each of the 15 cases who received weekly protocol and the protocol of three weekly 15 cases. Most 46-55 years old (60.0%) in the weekly protocol and also 60.0% at three weekly protocol. Parity 3 or more, 73.3% and 66.7%. Elementary education level (33.3% and 73.3%). Class III of ward (73.3% and 66.7%). Histopathology of epidermoid carcinoma (40.0%) and squamous cell carcinoma (40.0%). Stage IIB (73.3%) and IIIA (40.0%). At the weekly protocol, the average (mean) SCC antigen levels before treatment (SCC Pre Ag) 8.080 ± 13.151 mg / L and SCC antigen after the weekly protocol (SCC Post Ag) 3.067 ± 3.465 mg / L, with changes (decreased levels) amounting to 5.013 ± 12.000 mg / L. While the protocol three weekly average SCC Pre Ag ± 17.610 21.575 ug / L and Post SCC Ag is 8.074 ± 14.760 mg / L, with changes (decreased levels) for 9.536 ± 14.873 mg / L. With a paired t test individually on a weekly and three weekly protocol obtained: First, there is no change in a significant SCC antigen levels before and after the third on the protocol of chemotherapy weekly. Second, there is a change in a significant SCC antigen levels before and after the third chemotherapy at three weekly protocol. Test done together with the independent t test acquired conclusions: there is no change in a significant SCC antigen levels before and after the third chemotherapy between the weekly protocol and three weekly protocols. Conclusion: there is no change in a significant SCC antigen levels before and after the third chemotherapy between the weekly protocol and three weekly protocols on advanced carcinoma of the cervix uteri. [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , Milhan and , Prof. Dr. dr. Ibnu Pranoto, SpAnd, SpOG(K) (2012) PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI STADIUM LANJUT. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56624 |
| spellingShingle | ETD , Milhan , Prof. Dr. dr. Ibnu Pranoto, SpAnd, SpOG(K) PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI STADIUM LANJUT |
| title | PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL
CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN
PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI
STADIUM LANJUT |
| title_full | PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL
CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN
PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI
STADIUM LANJUT |
| title_fullStr | PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL
CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN
PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI
STADIUM LANJUT |
| title_full_unstemmed | PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL
CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN
PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI
STADIUM LANJUT |
| title_short | PERBANDINGAN PERUBAHAN KADAR ANTIGEN SQUAMOUS CELL
CARCINOMA PADA KEMOTERAPI PROTOKOL MINGGUAN DAN
PROTOKOL TIGA MINGGUAN PADA KARSINOMA SERVIKS UTERI
STADIUM LANJUT |
| title_sort | perbandingan perubahan kadar antigen squamous cell carcinoma pada kemoterapi protokol mingguan dan protokol tiga mingguan pada karsinoma serviks uteri stadium lanjut |
| topic | ETD |
| work_keys_str_mv | AT milhan perbandinganperubahankadarantigensquamouscellcarcinomapadakemoterapiprotokolmingguandanprotokoltigamingguanpadakarsinomaserviksuteristadiumlanjut AT profdrdribnupranotospandspogk perbandinganperubahankadarantigensquamouscellcarcinomapadakemoterapiprotokolmingguandanprotokoltigamingguanpadakarsinomaserviksuteristadiumlanjut |