| Summary: | Along with aging, bone tissue in women body losses its calcium content.
This condition, called osteoporosis, is a metabolic skeletal disease characterized
by low bone mass and microarchitectural deterioration. Perimenopause and
postmenopause women had greater risk for suffering osteoporosis. The dual
energy X-ray absorptiometry (DEXA) is a gold standard for diagnosing
osteoporosis by measuring bone mineral density (BMD), but had limited
availability in hospitals.
The process of osteoporosis is governed by a number of hormones,
including estrogen. Another hormone associated with osteoporosis is parathyroid
hormone that acts as a regulator of the balance of bone metabolism and
pathophysiology associated with type 2 primary osteoporosis is due to low serum
calcium balance. Changes in calcium ion concentration caused by the reduction in
PTH levels, so that serum levels of PTH can be used as a marker of the status
calcium in the body. The aim of this study is to understand the profile and the
correlation of parathyroid hormone and serum calcium by a score of BMD in
postmenopausal and perimenopause women's groups.
This is a cross-sectional study. The subjects are women more than 45
years old. Eighty three subjects were included in this study, based on hip bone
density score consisted of 35 normal (42,4%), 31 osteopenic (37,3%) and 17
osteoporotic subjects (20,5%). Based on lumbal bone density score 25 subjects
(30,1%) are categorized as osteoporosis, 22 subjects (26,5%) osteopenic and 36
subjects (43,4%) normal. There is statistically significant weak negative
correlation between serum PTH level and lumbal Bone Mineral Density in
perimenopausal and postmenopausal subjects (r= -0,221, p= 0,045). There is no
correlation between serum PTH level and serum calcium level in perimenopausal
and postmenopausal subjects (r= -0,090, p= 0,417).
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