| Summary: | Background: Seizures in neonates is often associated with neurologic disorder in the early of life, of which includes epilepsy. There are several prognostic factors that influence the development of epilepsy in these patients.
Objective: To determine prognostic factors that influences the occurrence of epilepsy in the first 2 years of life among patients with history of neonatal seizures.
Method: We performed a retrospective cohort study on patients with neonatal seizures in Sardjito Hospital during 2004-2009. Prognostic factors to be observed were gender, family history of epilepsy, hypoglycemia, assisted labor, hypoxic ischemic encephalopathy, preterm infant and epileptic state.
Results: Hypoxic ischemic encephalopathy and epileptic state increased the risk of epilepsy [HR 5,8 (CI95% 1,63 to 20, 43) and HR 6,3 (CI 95% 2,0 to 19,70)]. Assisted labor, preterm infant, neonatal hypoglycemia, family history of epilepsy and gender did not increase the risk of epilepsy in the first 2 years of life.
Conclusion: Hypoxic ischemic encephalopathy and epileptic state in neonates presenting with seizure has unfavorable prognosis of having epilepsy in two years of life.
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