| Summary: | Premature rupture of membranes (PROM) is rupture of membranes
without labor followed in pregnancy at term or preterm. PROM affects 10-20%
of all deliveries, and is associated with increased morbidity and neonatal and
maternal mortality worldwide. PROM cause preterm labor resulting in the birth
of low birth weight babies are a major cause of infant mortality.The research
objective was to determine differences in plasma levels of vitamin C among
pregnant women with preterm PROM and preterm PROM without. Determine
the correlation between vitamin C and preterm premature rupture of
membrane.
The design of observational analytic study with case control study
design, in Bantul District Hospital Panembahan Senopati from November
2011 until February 2012. Technique Nonprobability sampling, type of
consecutive. Sample size was calculated to test the hypothesis against the
odds ratios for case-control study, obtained a sample of 40 people, 20 cases
and 20 controls without preterm PROM.. Total plasma vitamin C levels
examined in the laboratory of biochemistry FK-UGM, 2.4
dinitrophenylhydrazine calorimetric method. Normal total plasma
concentrations of � 0.6 mg / dl. Data were analyzed by univariate, bivariate
with independent t test, chi square test, fisher's exact test, multivariate
analysis with logistic regression. The results univariate analysis of mean
plasma levels of vitamin C in the group the preterm PROM and without the
preterm PROM was 0.9 vs 1.1. The results obtained by independent t test p =
0.24 (IK95% -0.55-0.14). The results of logistic regression test values
obtained for the levels vitamin C plasma OR 2.80, (IK95% 0.38-20.79),
anemia OR 6.42, (IK95% 0.89-46.45) infections OR 6.54 (IK95% 0.32-21.72)
PROM history previous values obtained OR 2.65, (IK95% 0.32-21.72).
Conclusions plasma vitamin C levels did not differ between pregnant
women with preterm premature rupture of membranes and without preterm
premature rupture of membranes. Low plasma vitamin C levels are not
associated with the incidence of premature rupture of membranes.
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