ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA INVITRO
Pentagamavunon-0 (PGV-0) was derived from curcumin by molecule modification which was a preeminent product of Faculty of Pharmacy GMU and developed as a new potential analgetic-antiinflammatory agent. , it was discovered that PGV-0 had a poor bioavailability due to its low solubility. Nanoparticle e...
| Päätekijät: | , |
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| Aineistotyyppi: | Opinnäyte |
| Julkaistu: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| Aiheet: |
| _version_ | 1826045770913021952 |
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| author | , DIAN PURWITA SARI , Dr. rer. nat. Ronny Martien, M.Si., |
| author_facet | , DIAN PURWITA SARI , Dr. rer. nat. Ronny Martien, M.Si., |
| author_sort | , DIAN PURWITA SARI |
| collection | UGM |
| description | Pentagamavunon-0 (PGV-0) was derived from curcumin by molecule
modification which was a preeminent product of Faculty of Pharmacy GMU and
developed as a new potential analgetic-antiinflammatory agent. , it was
discovered that PGV-0 had a poor bioavailability due to its low solubility.
Nanoparticle encapsulation using chitosan was expected to increase PGV-0
solubility profile in order to gain the bioavailability by enhancing the transport
through biological membrane. The aim of this research was to produce chitosan-
PGV-0 nanoparticle using low viscous and medium viscous chitosan and to do an
invitro study for determining the permeation force.
method. The
PGV-0 nanoparticle encapsulation using low viscous and medium
viscous chitosan was carried out by the ionic gelation preparation
was optimized by gradual production scale, 500 µL, 15 mL, and 100 mL.
Chitosan-PGV-0 nanoparticle characterization included the measurement of
particle size, distribution, zeta potential, morphological shape, entrapment
efficiency and entrapment stability. Chitosan-PGV-0 nanoparticle permeation
force was evaluated by invitro study represented by cellular uptake and diffusion
test.
formula The selected were NCPL (Low Viscous Chitosan 0,05% |
| first_indexed | 2024-03-13T22:42:29Z |
| format | Thesis |
| id | oai:generic.eprints.org:100437 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:42:29Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1004372016-03-04T08:46:05Z https://repository.ugm.ac.id/100437/ ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA INVITRO , DIAN PURWITA SARI , Dr. rer. nat. Ronny Martien, M.Si., ETD Pentagamavunon-0 (PGV-0) was derived from curcumin by molecule modification which was a preeminent product of Faculty of Pharmacy GMU and developed as a new potential analgetic-antiinflammatory agent. , it was discovered that PGV-0 had a poor bioavailability due to its low solubility. Nanoparticle encapsulation using chitosan was expected to increase PGV-0 solubility profile in order to gain the bioavailability by enhancing the transport through biological membrane. The aim of this research was to produce chitosan- PGV-0 nanoparticle using low viscous and medium viscous chitosan and to do an invitro study for determining the permeation force. method. The PGV-0 nanoparticle encapsulation using low viscous and medium viscous chitosan was carried out by the ionic gelation preparation was optimized by gradual production scale, 500 µL, 15 mL, and 100 mL. Chitosan-PGV-0 nanoparticle characterization included the measurement of particle size, distribution, zeta potential, morphological shape, entrapment efficiency and entrapment stability. Chitosan-PGV-0 nanoparticle permeation force was evaluated by invitro study represented by cellular uptake and diffusion test. formula The selected were NCPL (Low Viscous Chitosan 0,05% [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , DIAN PURWITA SARI and , Dr. rer. nat. Ronny Martien, M.Si., (2012) ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA INVITRO. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=56374 |
| spellingShingle | ETD , DIAN PURWITA SARI , Dr. rer. nat. Ronny Martien, M.Si., ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA INVITRO |
| title | ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN
KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG
SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA
INVITRO |
| title_full | ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN
KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG
SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA
INVITRO |
| title_fullStr | ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN
KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG
SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA
INVITRO |
| title_full_unstemmed | ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN
KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG
SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA
INVITRO |
| title_short | ENKAPSULASI NANOPARTIKEL PENTAGAMAVUNON-0 DENGAN
KITOSAN VISKOSITAS RENDAH DAN VISKOSITAS SEDANG
SERTA EVALUASINYA MELALUI UJI TRANSPORT OBAT SECARA
INVITRO |
| title_sort | enkapsulasi nanopartikel pentagamavunon 0 dengan kitosan viskositas rendah dan viskositas sedang serta evaluasinya melalui uji transport obat secara invitro |
| topic | ETD |
| work_keys_str_mv | AT dianpurwitasari enkapsulasinanopartikelpentagamavunon0dengankitosanviskositasrendahdanviskositassedangsertaevaluasinyamelaluiujitransportobatsecarainvitro AT drrernatronnymartienmsi enkapsulasinanopartikelpentagamavunon0dengankitosanviskositasrendahdanviskositassedangsertaevaluasinyamelaluiujitransportobatsecarainvitro |