EFEK DIET SUSPENSI SERBUK UMBI SUWEG (Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP PROFIL LEMAK TUBUH PADA TIKUS JANTAN YANG DIBERI DIET LEMAK TINGGI
The study was done to know the effects of diet Suweg (Amorphopallus campanulatus (Roxb.) Bl.) tubers powder suspensions to parameters of body fat profiles in male rats were given a high-fat diet (DLT). Parameters observed include total cholesterol, triglycerides, LDL-cholesterol, and HDL-cholesterol...
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2012
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| _version_ | 1797032804946542592 |
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| author | , IKA PUSPITANINGRUM , Ika Puspita Sari, M.Si., PhD., Apt |
| author_facet | , IKA PUSPITANINGRUM , Ika Puspita Sari, M.Si., PhD., Apt |
| author_sort | , IKA PUSPITANINGRUM |
| collection | UGM |
| description | The study was done to know the effects of diet Suweg (Amorphopallus
campanulatus (Roxb.) Bl.) tubers powder suspensions to parameters of body fat profiles in male rats were given a high-fat diet (DLT). Parameters observed
include total cholesterol, triglycerides, LDL-cholesterol, and HDL-cholesterol and
the activity of enzymes that play a role in the absorption of fat, which is lipase
enzyme. It is also observed an overview atherosclerosis and nonalcoholic fatty
liver diseases.
The research was done with pre and post test randomized control group
design. Animal trials Wistar male rats as much as 40 divided by 8 groups. Group I (normal control) were given a standard diet, II were given a standard diet in days 31-45, III (negative control) were Na CMC 0,5%, groups IV, V and VI were given Suweg tubers suspensions 360, 720 and 1440 mg/kg, VII and VIII (positive control) were given a dose of Orlistat and Glucomannan 10,8 and 90 mg/kg. Groups III-VIII were given DLT which is mixtures standard feed, oil pigs and chicken egg yolks (16:3:1) for 45 days, group II for 30 days and the treatment of test compounds given an oral for 15 days. Measurement of body fat profiles done on days 0, 30, and 45, while the lipase enzyme activity measurements done on days 30 and 45. At the end of the treatment performed histopathology analysis to liver organ and the aorta. Levels of body fat and activity profile of lipase obtained statistically analyzed with the Kruskal-Wallis and Mann-Whitney using SPSS release 16.
The results obtained Suweg tubers suspensions 360 mg/kgBB rats can
significantly reduce total cholesterol (p=0,047) and LDL-cholesterol (p=0,012)
with the percentage decreased by 18,65% and 34,15%, and the effect is
comparable with Orlistat. Suweg tubers suspensions 720 mg/kb can significantly reduce total cholesterol (p=0,009), triglycerides (p=0,043), and LDL-cholesterol (p=0,023) with the percentage decreased by 33,60%, 24,24% and 55,16%, and to increase HDL-cholesterol levels (p=0,021) with the percentage increase 12,26%, and the effect is comparable with Orlistat, but can�t reduce lipase enzyme activity. Suweg tubers suspensions 1440 mg/kg can�t reduce total cholesterol, triglycerides, and LDL-cholesterol and can�t increase HDL-cholesterol levels. Suweg tubers suspensions 360, 720, and 1440 mg/kg showed no fatty in liver cells and rat aorta |
| first_indexed | 2024-03-13T22:44:15Z |
| format | Thesis |
| id | oai:generic.eprints.org:100913 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:44:15Z |
| publishDate | 2012 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1009132016-03-04T08:47:04Z https://repository.ugm.ac.id/100913/ EFEK DIET SUSPENSI SERBUK UMBI SUWEG (Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP PROFIL LEMAK TUBUH PADA TIKUS JANTAN YANG DIBERI DIET LEMAK TINGGI , IKA PUSPITANINGRUM , Ika Puspita Sari, M.Si., PhD., Apt ETD The study was done to know the effects of diet Suweg (Amorphopallus campanulatus (Roxb.) Bl.) tubers powder suspensions to parameters of body fat profiles in male rats were given a high-fat diet (DLT). Parameters observed include total cholesterol, triglycerides, LDL-cholesterol, and HDL-cholesterol and the activity of enzymes that play a role in the absorption of fat, which is lipase enzyme. It is also observed an overview atherosclerosis and nonalcoholic fatty liver diseases. The research was done with pre and post test randomized control group design. Animal trials Wistar male rats as much as 40 divided by 8 groups. Group I (normal control) were given a standard diet, II were given a standard diet in days 31-45, III (negative control) were Na CMC 0,5%, groups IV, V and VI were given Suweg tubers suspensions 360, 720 and 1440 mg/kg, VII and VIII (positive control) were given a dose of Orlistat and Glucomannan 10,8 and 90 mg/kg. Groups III-VIII were given DLT which is mixtures standard feed, oil pigs and chicken egg yolks (16:3:1) for 45 days, group II for 30 days and the treatment of test compounds given an oral for 15 days. Measurement of body fat profiles done on days 0, 30, and 45, while the lipase enzyme activity measurements done on days 30 and 45. At the end of the treatment performed histopathology analysis to liver organ and the aorta. Levels of body fat and activity profile of lipase obtained statistically analyzed with the Kruskal-Wallis and Mann-Whitney using SPSS release 16. The results obtained Suweg tubers suspensions 360 mg/kgBB rats can significantly reduce total cholesterol (p=0,047) and LDL-cholesterol (p=0,012) with the percentage decreased by 18,65% and 34,15%, and the effect is comparable with Orlistat. Suweg tubers suspensions 720 mg/kb can significantly reduce total cholesterol (p=0,009), triglycerides (p=0,043), and LDL-cholesterol (p=0,023) with the percentage decreased by 33,60%, 24,24% and 55,16%, and to increase HDL-cholesterol levels (p=0,021) with the percentage increase 12,26%, and the effect is comparable with Orlistat, but can�t reduce lipase enzyme activity. Suweg tubers suspensions 1440 mg/kg can�t reduce total cholesterol, triglycerides, and LDL-cholesterol and can�t increase HDL-cholesterol levels. Suweg tubers suspensions 360, 720, and 1440 mg/kg showed no fatty in liver cells and rat aorta [Yogyakarta] : Universitas Gadjah Mada 2012 Thesis NonPeerReviewed , IKA PUSPITANINGRUM and , Ika Puspita Sari, M.Si., PhD., Apt (2012) EFEK DIET SUSPENSI SERBUK UMBI SUWEG (Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP PROFIL LEMAK TUBUH PADA TIKUS JANTAN YANG DIBERI DIET LEMAK TINGGI. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=57642 |
| spellingShingle | ETD , IKA PUSPITANINGRUM , Ika Puspita Sari, M.Si., PhD., Apt EFEK DIET SUSPENSI SERBUK UMBI SUWEG (Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP PROFIL LEMAK TUBUH PADA TIKUS JANTAN YANG DIBERI DIET LEMAK TINGGI |
| title | EFEK DIET SUSPENSI SERBUK UMBI SUWEG
(Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP
PROFIL LEMAK TUBUH PADA TIKUS JANTAN
YANG DIBERI DIET LEMAK TINGGI |
| title_full | EFEK DIET SUSPENSI SERBUK UMBI SUWEG
(Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP
PROFIL LEMAK TUBUH PADA TIKUS JANTAN
YANG DIBERI DIET LEMAK TINGGI |
| title_fullStr | EFEK DIET SUSPENSI SERBUK UMBI SUWEG
(Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP
PROFIL LEMAK TUBUH PADA TIKUS JANTAN
YANG DIBERI DIET LEMAK TINGGI |
| title_full_unstemmed | EFEK DIET SUSPENSI SERBUK UMBI SUWEG
(Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP
PROFIL LEMAK TUBUH PADA TIKUS JANTAN
YANG DIBERI DIET LEMAK TINGGI |
| title_short | EFEK DIET SUSPENSI SERBUK UMBI SUWEG
(Amorphophallus campanulatus (Roxb.) Bl.) TERHADAP
PROFIL LEMAK TUBUH PADA TIKUS JANTAN
YANG DIBERI DIET LEMAK TINGGI |
| title_sort | efek diet suspensi serbuk umbi suweg amorphophallus campanulatus roxb bl terhadap profil lemak tubuh pada tikus jantan yang diberi diet lemak tinggi |
| topic | ETD |
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