| Summary: | Anemia is a major health problem around the world. World Health
Organization estimates that 44.5% of pre school children in Indonesia suffer from
anemia and iron deficiency is the major cause. Iron deficiency occurs due to
disruption of the balance between the iron supply and the body's iron needs. In
children under 5 years iron deficiency will cause disruption in their growth and
development. For that reasons iron deficiency in children should be detected as
early as possible.
Laboratory tests for the detection of iron deficiency divided into
hematologic and biochemical examination. Gold standard in the detection of iron
deficiency is bone marrow aspiration, but this examination are invasive and
difficult to implement. Ferritin is often used to detect iron deficiency but it has
various limitations. Reticulocyte hemoglobin content (CHr) was introduced as a
new parameter for the identification of iron deficiency. This parameter measures
the levels of hemoglobin in the reticulocytes which is newly released from bone
marrow and expected to reflect the actual conditions in the bone marrow so it can
detect early iron deficiency. It is hoped that CHr can identify iron deficiency with
more cheaper, easy, and applicative method. The aims of this study are to
determine the diagnostic performance of CHr in the identification of iron
deficiency in children aged 6 months to 5 years.
This study is a cross sectional study to determine the diagnostic
performance of CHr. The subjects of this study were healthy children aged 6
months-5 years taken from Posyandu in Yogyakarta district and has obtained the
consent of their parent/guardian. CHr examination using flowcytometry method
by Advia 120 Hematology Analyzer. Ferritin examination using
electrochemiluminescens methods with Elecsys 1010. The results displayed in the
sensitivity, specificity, positive predictive value, and negative predictive value.
Determination of CHr cut off using ROC curves.
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