| Summary: | Background: Urinary tract infection (UTI) is a prevalent in children and
prompt diagnosis followed with adequate therapy will prevent long term
complications such as renal failure. Standard for diagnosing UTI is urine
culture, however, it is time consuming (3�5 days), relatively expensive, and
may be unavariable in some health facilities. Gram staining, nitrite and
leukocyte esterase of urine are considered to be potential alternatif method
to diagnose UTI.
Objective: This study was aimed to determine the diagnostic value of Gram
staining, nitrate and urine leukocyte esterase to diagnose UTI, composed the
gold standart of urine culture.
Method: This study is a diagnostic test with a cross-sectional design and was
performed in Dr Sardjito hospital, Yogyakarta. Urine samples were taken from
child with UTI suspicious (3-18 years old) by consecutive sampling, and who
fulfilled the inclusion and exclusion criteria. It examined by Gram staining
under microscopic examination, urinary nitrate and leukocyte esterase by
dipstick test, and urinary culture as the gold standard.
Result: About 140 children who fulfilled the inclusion and exclusion criteria
were included in the study. Triple parallel test (Gram stain, nitrite and
leukocyte esterase urine) was found that the sensitivity was 91,0% (95% CI:
84,0-98,0), specificity 92% (95% CI: 81,0-100), positive predictive value
97% (95% CI:92,0-100) and negative predictive value 79% (95% CI:63,0-
94,0), and positive likelihood ratio 10,9 (95% CI: 2,9-41,3).
Conclusion: Combination of Gram staining, nitrite and leukocyte esterase in
the urine had high sensitivity and specificity to diagnose UTI.
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