Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina
Copper is an essential element to all animals. At elevated concentrations, it is toxic and can participate in the formation of reactive oxygen species, leading to cellular damage. In this study, the ecotoxicological relevance of copper was investigated with freshwater mussels, Anodonta anatina. Whe...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis
2012
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| Online Access: | https://repository.ugm.ac.id/101283/1/Publication%20IV.pdf |
| _version_ | 1797032870151192576 |
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| author | Nugroho, Andhika Puspito Frank, Hartmut |
| author_facet | Nugroho, Andhika Puspito Frank, Hartmut |
| author_sort | Nugroho, Andhika Puspito |
| collection | UGM |
| description | Copper is an essential element to all animals. At elevated concentrations, it is toxic and can participate in the formation of reactive oxygen species, leading to
cellular damage. In this study, the ecotoxicological relevance of copper was investigated with freshwater mussels, Anodonta anatina. When the mussels were
exposed to copper at environmentally realistic concentrations, either via the water (0.3 mmol L1 Cu) or fed with Cu-loaded algae (equivalent to 0.06 mmol L1 Cu),
the level of thiobarbituric acid-reactive substances rose and glutathione decreased. This was associated with the induction of metallothionein and, relative to total protein, of glutathione reductase and the antioxidative enzymes superoxide dismutase, catalase, and glutathione peroxidase. But, since the overall protein-synthetic capacity was hampered by the copper insult, the activities of the enzymes relative to tissue weight and copper concentrations were depressed.
During depuration, most parameters started to normalize although not returning to control values within 12 days. |
| first_indexed | 2024-03-13T22:45:14Z |
| format | Article |
| id | oai:generic.eprints.org:101283 |
| institution | Universiti Gadjah Mada |
| language | English |
| last_indexed | 2024-03-13T22:45:14Z |
| publishDate | 2012 |
| publisher | Taylor & Francis |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1012832015-03-24T01:37:59Z https://repository.ugm.ac.id/101283/ Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina Nugroho, Andhika Puspito Frank, Hartmut Biological Sciences Copper is an essential element to all animals. At elevated concentrations, it is toxic and can participate in the formation of reactive oxygen species, leading to cellular damage. In this study, the ecotoxicological relevance of copper was investigated with freshwater mussels, Anodonta anatina. When the mussels were exposed to copper at environmentally realistic concentrations, either via the water (0.3 mmol L1 Cu) or fed with Cu-loaded algae (equivalent to 0.06 mmol L1 Cu), the level of thiobarbituric acid-reactive substances rose and glutathione decreased. This was associated with the induction of metallothionein and, relative to total protein, of glutathione reductase and the antioxidative enzymes superoxide dismutase, catalase, and glutathione peroxidase. But, since the overall protein-synthetic capacity was hampered by the copper insult, the activities of the enzymes relative to tissue weight and copper concentrations were depressed. During depuration, most parameters started to normalize although not returning to control values within 12 days. Taylor & Francis 2012-05 Article PeerReviewed application/pdf en https://repository.ugm.ac.id/101283/1/Publication%20IV.pdf Nugroho, Andhika Puspito and Frank, Hartmut (2012) Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina. Toxicological and Environmental Chemistry, 94 (5-6). pp. 918-929. ISSN 0277-2248 http://dx.doi.org/10.1080/02772248.2012.675156 10.1080/02772248.2012.675156 |
| spellingShingle | Biological Sciences Nugroho, Andhika Puspito Frank, Hartmut Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina |
| title | Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina |
| title_full | Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina |
| title_fullStr | Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina |
| title_full_unstemmed | Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina |
| title_short | Effects of copper on lipid peroxidation,glutathione,metallothionein, and antioxidative enzymes in the freshwater mussel Anodonta anatina |
| title_sort | effects of copper on lipid peroxidation glutathione metallothionein and antioxidative enzymes in the freshwater mussel anodonta anatina |
| topic | Biological Sciences |
| url | https://repository.ugm.ac.id/101283/1/Publication%20IV.pdf |
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