An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite
We developed hydroxyapatite (HA) granules made from local raw materials (GranuMaS™), which have been fabricated using a novel method (Patent (Pending) No. PI 2004 0748). GranuMaS™ have been fully characterized using X-ray diffraction, scanning electron microscopy, energy dispersive x-ray, Four...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
AO Research Institute Davos
2008
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/10382/1/v016supp02a055.pdf |
| _version_ | 1796875795348586496 |
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| author | Zulkifly, Ahmad Hafiz Khalid, Kamarul Ariffin Aziz, Mohd Yusof Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Che Ahmad, Aminudin Zakaria@Mohamad, Zamzuri Fazan, Fazilah |
| author_facet | Zulkifly, Ahmad Hafiz Khalid, Kamarul Ariffin Aziz, Mohd Yusof Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Che Ahmad, Aminudin Zakaria@Mohamad, Zamzuri Fazan, Fazilah |
| author_sort | Zulkifly, Ahmad Hafiz |
| collection | IIUM |
| description | We developed hydroxyapatite (HA)
granules made from local raw materials (GranuMaS™),
which have been fabricated using a novel method
(Patent (Pending) No. PI 2004 0748). GranuMaS™
have been fully characterized using X-ray diffraction,
scanning electron microscopy, energy dispersive x-ray,
Fourier transform infra-red spectroscopy and
inductively coupled plasma methods. It has also been
shown to comply with the ASTM F1185 - 88 (1993)
specification standards.
Biocompatibility studies have been performed on the
product, which include neutral red cytotoxicity assay
using cultured fibroblast and CRL-1427 osteoblast cells;
MTT (Tetrazolium Salt) assay; cytotoxicity studies for
apoptosis using Acridine Orange / Propidium Iodide
(AO/PI) dual staining of V79 cells in DMEM; and
COMET assay genotoxicity studies using L-929
(normal mouse epithelial) cells.
An in vivo implantation study involving New Zealand
White rabbits were carried out in the course of this
study. |
| first_indexed | 2024-03-05T22:43:38Z |
| format | Article |
| id | oai:generic.eprints.org:10382 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:43:38Z |
| publishDate | 2008 |
| publisher | AO Research Institute Davos |
| record_format | dspace |
| spelling | oai:generic.eprints.org:103822013-12-16T00:42:25Z http://irep.iium.edu.my/10382/ An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite Zulkifly, Ahmad Hafiz Khalid, Kamarul Ariffin Aziz, Mohd Yusof Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Che Ahmad, Aminudin Zakaria@Mohamad, Zamzuri Fazan, Fazilah RD701 Orthopedics We developed hydroxyapatite (HA) granules made from local raw materials (GranuMaS™), which have been fabricated using a novel method (Patent (Pending) No. PI 2004 0748). GranuMaS™ have been fully characterized using X-ray diffraction, scanning electron microscopy, energy dispersive x-ray, Fourier transform infra-red spectroscopy and inductively coupled plasma methods. It has also been shown to comply with the ASTM F1185 - 88 (1993) specification standards. Biocompatibility studies have been performed on the product, which include neutral red cytotoxicity assay using cultured fibroblast and CRL-1427 osteoblast cells; MTT (Tetrazolium Salt) assay; cytotoxicity studies for apoptosis using Acridine Orange / Propidium Iodide (AO/PI) dual staining of V79 cells in DMEM; and COMET assay genotoxicity studies using L-929 (normal mouse epithelial) cells. An in vivo implantation study involving New Zealand White rabbits were carried out in the course of this study. AO Research Institute Davos 2008 Article PeerReviewed application/pdf en http://irep.iium.edu.my/10382/1/v016supp02a055.pdf Zulkifly, Ahmad Hafiz and Khalid, Kamarul Ariffin and Aziz, Mohd Yusof and Mohamed Amin, Mohamed Azril and Awang, Mohd Shukrimi and Mohd Yusof, Nazri and Che Ahmad, Aminudin and Zakaria@Mohamad, Zamzuri and Fazan, Fazilah (2008) An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite. European Cells and Materials, 16 (supp 2). p. 55. ISSN 1473-2262 http://ecmjournal.org/journal/supplements/vol016supp02/pdf/v016supp02a055.pdf |
| spellingShingle | RD701 Orthopedics Zulkifly, Ahmad Hafiz Khalid, Kamarul Ariffin Aziz, Mohd Yusof Mohamed Amin, Mohamed Azril Awang, Mohd Shukrimi Mohd Yusof, Nazri Che Ahmad, Aminudin Zakaria@Mohamad, Zamzuri Fazan, Fazilah An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite |
| title | An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite |
| title_full | An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite |
| title_fullStr | An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite |
| title_full_unstemmed | An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite |
| title_short | An in vivo implantation study in New Zealand white rabbits for granular hydroxyapatite |
| title_sort | in vivo implantation study in new zealand white rabbits for granular hydroxyapatite |
| topic | RD701 Orthopedics |
| url | http://irep.iium.edu.my/10382/1/v016supp02a055.pdf |
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