The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring
The aims of this study were to assess the differences in the percentages of abnormal morphology between the epididymal and testicular spermatozoa of mature male offspring mice whose mothers were injected with various doses of lead acetate during gestation. Seventy two healthy female mice were divide...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Kulliyyah of Medicine, International Islamic University Malaysia
2009
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/10663/1/Effect_of_lead_on_the_morphology_of_epididymal_and_testicular_spermatozoa.mht |
| _version_ | 1825645185809252352 |
|---|---|
| author | Al-Ani, Imad Matloub Dally Al-Khfaji , Imaa'am Fakhrildin, Mihamed-Baqer Mangalo, Han'aa Al-Obaidi, Salim Rasheed |
| author_facet | Al-Ani, Imad Matloub Dally Al-Khfaji , Imaa'am Fakhrildin, Mihamed-Baqer Mangalo, Han'aa Al-Obaidi, Salim Rasheed |
| author_sort | Al-Ani, Imad Matloub Dally |
| collection | IIUM |
| description | The aims of this study were to assess the differences in the percentages of abnormal morphology between the epididymal and testicular spermatozoa of mature male offspring mice whose mothers were injected with various doses of lead acetate during gestation. Seventy two healthy female mice were divided into three major groups according to the number of injections involving 1, 2 or 3 injections at 8th day; 8th and 13th days; and 8th, 13th and 18th days of gestation period, respectively. Each major group was subdivided into four minor groups according to of the dosage of lead administration of (0, 25, 50 and 100) mg/Kg. The percentages of abnormal morphology of epididymal and testicular spermatozoa were studied and the data were statistically analyzed. The results of the present study proved that an increased number of injections and/or dose of lead acetate injected to the mothers during gestation cause an elevation in the percentage of abnormal morphology of both epididymal and testicular spermatozoa of the male mice offspring. In conclusion this study demonstrated that lead acetate when exposed prenatally have toxic effects on the sperm abnormal morphology in the offspring male mice most likely by interfering with the phase(s) of spermatogenesis and/or spermiogenesis.
|
| first_indexed | 2024-03-05T22:43:55Z |
| format | Article |
| id | oai:generic.eprints.org:10663 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:43:55Z |
| publishDate | 2009 |
| publisher | Kulliyyah of Medicine, International Islamic University Malaysia |
| record_format | dspace |
| spelling | oai:generic.eprints.org:106632015-12-18T02:49:09Z http://irep.iium.edu.my/10663/ The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring Al-Ani, Imad Matloub Dally Al-Khfaji , Imaa'am Fakhrildin, Mihamed-Baqer Mangalo, Han'aa Al-Obaidi, Salim Rasheed QM Human anatomy QP Physiology RB Pathology The aims of this study were to assess the differences in the percentages of abnormal morphology between the epididymal and testicular spermatozoa of mature male offspring mice whose mothers were injected with various doses of lead acetate during gestation. Seventy two healthy female mice were divided into three major groups according to the number of injections involving 1, 2 or 3 injections at 8th day; 8th and 13th days; and 8th, 13th and 18th days of gestation period, respectively. Each major group was subdivided into four minor groups according to of the dosage of lead administration of (0, 25, 50 and 100) mg/Kg. The percentages of abnormal morphology of epididymal and testicular spermatozoa were studied and the data were statistically analyzed. The results of the present study proved that an increased number of injections and/or dose of lead acetate injected to the mothers during gestation cause an elevation in the percentage of abnormal morphology of both epididymal and testicular spermatozoa of the male mice offspring. In conclusion this study demonstrated that lead acetate when exposed prenatally have toxic effects on the sperm abnormal morphology in the offspring male mice most likely by interfering with the phase(s) of spermatogenesis and/or spermiogenesis. Kulliyyah of Medicine, International Islamic University Malaysia 2009-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/10663/1/Effect_of_lead_on_the_morphology_of_epididymal_and_testicular_spermatozoa.mht Al-Ani, Imad Matloub Dally and Al-Khfaji , Imaa'am and Fakhrildin, Mihamed-Baqer and Mangalo, Han'aa and Al-Obaidi, Salim Rasheed (2009) The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring. International Medical Journal Malaysia, 10 (1). ISSN 1823-4631 http://www.e-imj.com/ |
| spellingShingle | QM Human anatomy QP Physiology RB Pathology Al-Ani, Imad Matloub Dally Al-Khfaji , Imaa'am Fakhrildin, Mihamed-Baqer Mangalo, Han'aa Al-Obaidi, Salim Rasheed The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring |
| title | The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring
|
| title_full | The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring
|
| title_fullStr | The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring
|
| title_full_unstemmed | The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring
|
| title_short | The effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring
|
| title_sort | effect of lead exposure of mice during pregnancy on the morphology of epididymal and testicular spermatozoa of their offspring |
| topic | QM Human anatomy QP Physiology RB Pathology |
| url | http://irep.iium.edu.my/10663/1/Effect_of_lead_on_the_morphology_of_epididymal_and_testicular_spermatozoa.mht |
| work_keys_str_mv | AT alaniimadmatloubdally theeffectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT alkhfajiimaaam theeffectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT fakhrildinmihamedbaqer theeffectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT mangalohanaa theeffectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT alobaidisalimrasheed theeffectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT alaniimadmatloubdally effectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT alkhfajiimaaam effectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT fakhrildinmihamedbaqer effectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT mangalohanaa effectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring AT alobaidisalimrasheed effectofleadexposureofmiceduringpregnancyonthemorphologyofepididymalandtesticularspermatozoaoftheiroffspring |