Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl
Bioassay-guided isolation of methanol extract revealed that medium polar fraction of the extract contained a few compounds that inhibited the growth of dermatophytes skin caused diseases. This confirmed the traditional usages of the stem barks of Entada spiralis by Malays in the old time, as a soap,...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
2011
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| Online Access: | http://irep.iium.edu.my/10684/1/POSTER.pdf |
| _version_ | 1796875815331299328 |
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| author | Mat So'ad, Siti Zaiton Harun, Aiza Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini |
| author_facet | Mat So'ad, Siti Zaiton Harun, Aiza Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini |
| author_sort | Mat So'ad, Siti Zaiton |
| collection | IIUM |
| description | Bioassay-guided isolation of methanol extract revealed that medium polar fraction of the extract contained a few compounds that inhibited the growth of dermatophytes skin caused diseases. This confirmed the traditional usages of the stem barks of Entada spiralis by Malays in the old time, as a soap, shampoo and scrub during the treatment of skin problems. Minimum inhibitory concentration of the fraction gave a significant value for the effect on selected dermatophytes which are T. rubrum, T. mentagrophytes and M. gypseum. Out of the five bioactive compounds isolated we will discuss one(1)of the compound which is proposed as a novel compound. The structural elucidation of the compound were based on spectroscopic analysis by using 1H-NMR, 13CNMR, DEPT, HMBC and HMQC. The mass spectrum, FTIR and UV were also used to support our data. From the structural elucidation,the compound is suggested as a triterpenoidal saponin which has never been reported elsewhere.
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| first_indexed | 2024-03-05T22:43:56Z |
| format | Proceeding Paper |
| id | oai:generic.eprints.org:10684 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:43:56Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oai:generic.eprints.org:106842012-02-23T07:11:45Z http://irep.iium.edu.my/10684/ Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl Mat So'ad, Siti Zaiton Harun, Aiza Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini QD Chemistry QR180 Immunology RS Pharmacy and materia medica Bioassay-guided isolation of methanol extract revealed that medium polar fraction of the extract contained a few compounds that inhibited the growth of dermatophytes skin caused diseases. This confirmed the traditional usages of the stem barks of Entada spiralis by Malays in the old time, as a soap, shampoo and scrub during the treatment of skin problems. Minimum inhibitory concentration of the fraction gave a significant value for the effect on selected dermatophytes which are T. rubrum, T. mentagrophytes and M. gypseum. Out of the five bioactive compounds isolated we will discuss one(1)of the compound which is proposed as a novel compound. The structural elucidation of the compound were based on spectroscopic analysis by using 1H-NMR, 13CNMR, DEPT, HMBC and HMQC. The mass spectrum, FTIR and UV were also used to support our data. From the structural elucidation,the compound is suggested as a triterpenoidal saponin which has never been reported elsewhere. 2011-11-14 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/10684/1/POSTER.pdf Mat So'ad, Siti Zaiton and Harun, Aiza and Mohd Hassan, Norazian and Che Mohd Ramli, Neni Kartini (2011) Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl. In: International Conference on Natural Products ICNP 2011, 14-16 November 2011, Putrajaya, Malaysia. http://www.icnp2011.upm.edu.my |
| spellingShingle | QD Chemistry QR180 Immunology RS Pharmacy and materia medica Mat So'ad, Siti Zaiton Harun, Aiza Mohd Hassan, Norazian Che Mohd Ramli, Neni Kartini Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl |
| title | Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl |
| title_full | Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl |
| title_fullStr | Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl |
| title_full_unstemmed | Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl |
| title_short | Structural elucidation of a major active compounds from the stem barks of Entada spiralis Ridl |
| title_sort | structural elucidation of a major active compounds from the stem barks of entada spiralis ridl |
| topic | QD Chemistry QR180 Immunology RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/10684/1/POSTER.pdf |
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