Histological liver changes in streptozotocin induced diabetic mice
Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experimen...
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| Format: | Article |
| Language: | English |
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Kulliyyah of Medicine, International Islamic University Malaysia
2009
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| Online Access: | http://irep.iium.edu.my/11004/1/Histological_Liver_Changes_in_Streptozotocin.mht |
| _version_ | 1796875844245782528 |
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| author | Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R. |
| author_facet | Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R. |
| author_sort | Al-Ani, Imad Matloub Dally |
| collection | IIUM |
| description | Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experiments were performed using a single dose of STZ (150mg/Kg. I.P.). Animals were killed two, four and six weeks after injection. The relative percentage of liver weight and liver histology were studied. The results showed several morphological and histological alterations in liver tissues, indicated by increase in the liver percentage of liver weight, glycogen reduction, associated with lipid deposition, inflammatory cells infiltration and Kupffer cells hyperplasia. Furthermore, this study illustrated the worsening of liver histology over a short time in STZ diabetic mice. |
| first_indexed | 2024-03-05T22:44:19Z |
| format | Article |
| id | oai:generic.eprints.org:11004 |
| institution | International Islamic University Malaysia |
| language | English |
| last_indexed | 2024-03-05T22:44:19Z |
| publishDate | 2009 |
| publisher | Kulliyyah of Medicine, International Islamic University Malaysia |
| record_format | dspace |
| spelling | oai:generic.eprints.org:110042015-12-18T02:48:46Z http://irep.iium.edu.my/11004/ Histological liver changes in streptozotocin induced diabetic mice Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R. QM Human anatomy QP Physiology RB Pathology Streptozotocin (STZ) is selectively toxic to cells in the pancreatic islets. It is well known that STZ causes specific death of B cells and induces diabetes mellitus. This study has been conducted to detect the histological changes that could be induced in liver of adult diabetic mice. The experiments were performed using a single dose of STZ (150mg/Kg. I.P.). Animals were killed two, four and six weeks after injection. The relative percentage of liver weight and liver histology were studied. The results showed several morphological and histological alterations in liver tissues, indicated by increase in the liver percentage of liver weight, glycogen reduction, associated with lipid deposition, inflammatory cells infiltration and Kupffer cells hyperplasia. Furthermore, this study illustrated the worsening of liver histology over a short time in STZ diabetic mice. Kulliyyah of Medicine, International Islamic University Malaysia 2009-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/11004/1/Histological_Liver_Changes_in_Streptozotocin.mht Al-Ani, Imad Matloub Dally and Al-Mishadani, Nu’man S and Muslih, Raad K. and Hamoodi , Salim R. (2009) Histological liver changes in streptozotocin induced diabetic mice. International Medical Journal Malaysia, 8 (1). ISSN 1823-4631 http://www.e-imj.com/ |
| spellingShingle | QM Human anatomy QP Physiology RB Pathology Al-Ani, Imad Matloub Dally Al-Mishadani, Nu’man S Muslih, Raad K. Hamoodi , Salim R. Histological liver changes in streptozotocin induced diabetic mice |
| title | Histological liver changes in streptozotocin induced diabetic mice
|
| title_full | Histological liver changes in streptozotocin induced diabetic mice
|
| title_fullStr | Histological liver changes in streptozotocin induced diabetic mice
|
| title_full_unstemmed | Histological liver changes in streptozotocin induced diabetic mice
|
| title_short | Histological liver changes in streptozotocin induced diabetic mice
|
| title_sort | histological liver changes in streptozotocin induced diabetic mice |
| topic | QM Human anatomy QP Physiology RB Pathology |
| url | http://irep.iium.edu.my/11004/1/Histological_Liver_Changes_in_Streptozotocin.mht |
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