HUBUNGAN EKSPRESI p53 DAN hMLH1 DENGAN KARAKTERISTIK KLINIKOPATOLOGIK KARSINOMA KOLOREKTAL
Over expression of p53 protein has been documented in human malignancies and shown to be associated with poor prognosis. hMLHI is a mismatch repair gene usually found in hereditary nonpolyposis and colorectal cancer. However, the relation between p53-, hMLHI expression and clinicopathological charac...
| Main Authors: | , |
|---|---|
| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
|
| Subjects: |
| Summary: | Over expression of p53 protein has been documented in human malignancies
and shown to be associated with poor prognosis. hMLHI is a mismatch repair gene usually found in hereditary nonpolyposis and colorectal cancer. However, the relation between p53-, hMLHI expression and clinicopathological characteristic of colorectal carcinoma is still controversial.
Aim: To analyse the correlation of p53 and hMLHI expression in colorectal carcinoma cases with several clinicopathological characteristics using immunohistochemistry.
Method : 45 paraffin-preserved adenocarcinoma colorectal cases were collected from
Sardjito Hospital, Bethesda Hospital and Panti Rapih Hospital. The expression of p53 was detected using clone of DO-7 |
|---|