PERBANDINGAN EKSPRESI PROTEIN Bcl-XL SEL TROFOBLAS PLASENTA ANTARA PREEKLAMPSIA BERAT DENGAN KEHAMILAN NORMOTENSI
Background: Preeclampsia is one of the main causes behind maternal and perinatal mortality and morbidity. The pathogenesis remains unclear but recently many believes that the failure of spiral arteries remodelling will eventually lead to placental hypoxia. On preeclampsia complicated-pregnancy, the...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| Summary: | Background: Preeclampsia is one of the main causes behind maternal and perinatal
mortality and morbidity. The pathogenesis remains unclear but recently many
believes that the failure of spiral arteries remodelling will eventually lead to placental
hypoxia. On preeclampsia complicated-pregnancy, the trophoblast apoptosis is
considered being excessive. Eventhough this hypothesis is still understudy, it is
believed that trophoblast apoptosis regulation play a role in preeclampsia
complicated-pregnancy pathophysiology. Molecular apoptosis mechanism in human
is very complex and involves many signaling molecules, among them is Bcl-2. Bcl2�
s group consist of proapoptosis (Bax) and apoptosis inhibitor (Bcl-2 and Bcl-xL).
Objective: To compare the expression of Bcl-xLprotein on pregnancy trophoblast
between severe preeclampsia complicated-pregnancy and normotension pregnancy.
Method: This cross sectional study involves population of severe preeclampsia and
normotension patient that being treated at RSUP Sardjito from October 2011 until
March 2012. Placenta samples were obtained from 43 severe preeclampsia/eclampsia
complicated-pregnancy and 38 placentas from normotension pregnancy. Bcl-xL
protein expression was observed using immunohistochemistry technique. Statistical
analysis was done using independent t-test (p<0.05).
Result: There was significant difference Bcl-xL protein expression on trophoblast
cells in severe preeclampsia complicated-pregnancy group 1.29 ± 0.12 compared to
normotension pregnancy group 1.71 ± 0.14 with p=0.00. From the logitic regression
analysis reveals that the presence of severe preeclamsia has a consistent statistically
significant role to the Bcl-xL protein expression with p=0.000.
Conclusion: Bcl-xL protein expression is lower in severe preeclampsia complicatedpregnancy
compared to normotension pregnancy. |
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