| Summary: | Nifedipine has a relatively short elimination half-life (4 hours). Nifedipine in immediate-release dosage forms has hypotensive response. Nifedipine is absorbed rapidly and almost perfectly (90%) in the stomach. Based on the absorption properties in the stomach, nifedipine can be prepared in the sustained-release dosage forms as gelling floating-gastroretentive. Formulas used in this study were determined by using factorial design with the use of three factors, i.e. HPMC K4M (A), Carbopol 940 (B), and Eudragit RSPO (C) so that eight formulas were obtained. Tablet hardness, duration of floating, amount of drug which is released up to 360 minute (C360), and dissolution efficiency up to 360 minutes (DE360) were used as parameters of optimization. Based on the data obtained, they were analyzed using equation to find the contour plots. Moreover, the contour plots were used to determine the optimum formula. Based on desirability values, optimum formula with 39,39 mg of HPMC K4M, 33,64 mg of Carbopol, and 10 mg of Eudragit RSPO was obtained. The results of optimum formula had 4.9 Kg of tablet hardness, 1350 minutes of floating time, 8.4% of C360, and 3.8% of ED360. Release kinetics of the optimum formula of nifedipine tablet is fitted to zero-order equation.
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