| Summary: | Acne is an inflamative chronic skin disease which has multifactorial
pathogenesis such as sebaceous hyperplasia, follicular hiperkeratinization,
hipercolonization of Propionibacterium acnes, and inflammation. Oxidative
stress especially lipid peroxidation in purpose is one trigger inflammation in acne
vulgaris. Oxidative stress is also influenced by environmental factors and
ultraviolet (UV) light. The UV radiation in Yogyakarta is relatively higher
compare in other region. Effect of high UV will increase lipid peroxidation in the
skin so that the malondialdehyde (MDA) as the outcome of lipid peroxidation
will be increased and eventually lead to inflammation in acne. This research was
conducted to compare the levels of serum MDA in various degrees of severity of
acne vulgaris in Yogyakarta.
An observasional, descriptive, and cross sectional study was conducted
in Yogyakarta with a consecutive sampling method to achieve 60 male acne
subject. The combined acne severity classification (CASC) method is used to
determine the severity of acne. Statistical analysis uses one way analysis test of
variance and Spearman's rho correlation test with a significance value of p<0.05.
Sixty male acne subjects were divided into 3 groups, namely mild,
moderate, and severe acne. Each of these group consists of 20 subjects. Mild acne
showed MDA levels lower than moderate (p= 0.002) and severe acne (p=0.000)
and moderate acne also lower than severe acne (p=0.000). There were strong
positive correlation between MDA serum with acne lesion total count (p=0.000
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