ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1
THPGV-1 has been sucesfully synthesised by using the hydrogenation reaction methode where Pd/C was used as catalyst, hydrogen gas as source of hydrogen and PGV-1 as starting material. The reaction was carried out at room temperature for two hours and yielded THPGV-1 in 18% and three others side prod...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| author | , Fransiska Ayuningtyas Widyastani , Dr. Ritmaleni, S.Si |
| author_facet | , Fransiska Ayuningtyas Widyastani , Dr. Ritmaleni, S.Si |
| author_sort | , Fransiska Ayuningtyas Widyastani |
| collection | UGM |
| description | THPGV-1 has been sucesfully synthesised by using the hydrogenation reaction methode where Pd/C was used as catalyst, hydrogen gas as source of hydrogen and PGV-1 as starting material. The reaction was carried out at room temperature for two hours and yielded THPGV-1 in 18% and three others side products. The aim of this research was to elucidate this sructure of side products and to investigate the anti-inflamatory activity of THPGV-1. Structure elucidations were carried out by using the spectroscopic method (1H-NMR, 2D-NMR, IR and MS) and anti-inflamatory activity was performed by the method of carragenan-induced footpad edema. Anti-inflamtory activity THPGV-1 admnistered orally to mice a moment before carragenan injection. THPGV-1 was comparable to PGV-1. Swelling measurements performed every 30 minutes for 6 hours using calipers. The side products� structures are found 1,3-bis-(4'-hydroxy-3',5'-dimethyl) benzylcyclopentane (compound A) in 30.33% yield as white crystalline powder with MW= 338 g/mol, 2,5-bis-(4�-hydroxy-3�,5�-dimethyl)benzylcyclopentanol (compound B) in 7.04% yield as white crystalline powder with MW= 354 g/mol and and compound C is an isomer of compound B in 15.38% yield as white crystalline powder with MW= 354 g/mol. Anti-inflammatory activity can be seen in the results of that test in different dossage are 60,80,100,120 mg /Kg body weight with anti-inflamation zone percentage respectively 69.97 ± 1.71% |
| first_indexed | 2024-03-13T22:48:02Z |
| format | Thesis |
| id | oai:generic.eprints.org:118907 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:48:02Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1189072016-03-04T08:36:55Z https://repository.ugm.ac.id/118907/ ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1 , Fransiska Ayuningtyas Widyastani , Dr. Ritmaleni, S.Si ETD THPGV-1 has been sucesfully synthesised by using the hydrogenation reaction methode where Pd/C was used as catalyst, hydrogen gas as source of hydrogen and PGV-1 as starting material. The reaction was carried out at room temperature for two hours and yielded THPGV-1 in 18% and three others side products. The aim of this research was to elucidate this sructure of side products and to investigate the anti-inflamatory activity of THPGV-1. Structure elucidations were carried out by using the spectroscopic method (1H-NMR, 2D-NMR, IR and MS) and anti-inflamatory activity was performed by the method of carragenan-induced footpad edema. Anti-inflamtory activity THPGV-1 admnistered orally to mice a moment before carragenan injection. THPGV-1 was comparable to PGV-1. Swelling measurements performed every 30 minutes for 6 hours using calipers. The side products� structures are found 1,3-bis-(4'-hydroxy-3',5'-dimethyl) benzylcyclopentane (compound A) in 30.33% yield as white crystalline powder with MW= 338 g/mol, 2,5-bis-(4�-hydroxy-3�,5�-dimethyl)benzylcyclopentanol (compound B) in 7.04% yield as white crystalline powder with MW= 354 g/mol and and compound C is an isomer of compound B in 15.38% yield as white crystalline powder with MW= 354 g/mol. Anti-inflammatory activity can be seen in the results of that test in different dossage are 60,80,100,120 mg /Kg body weight with anti-inflamation zone percentage respectively 69.97 ± 1.71% [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , Fransiska Ayuningtyas Widyastani and , Dr. Ritmaleni, S.Si (2013) ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=58885 |
| spellingShingle | ETD , Fransiska Ayuningtyas Widyastani , Dr. Ritmaleni, S.Si ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1 |
| title | ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS
SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1 |
| title_full | ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS
SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1 |
| title_fullStr | ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS
SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1 |
| title_full_unstemmed | ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS
SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1 |
| title_short | ELUSIDASI STRUKTUR PRODUK SAMPING DARI HASIL SINTESIS
SENYAWA THPGV-1 DAN UJI ANTIINFLAMASI SENYAWA THPGV-1 |
| title_sort | elusidasi struktur produk samping dari hasil sintesis senyawa thpgv 1 dan uji antiinflamasi senyawa thpgv 1 |
| topic | ETD |
| work_keys_str_mv | AT fransiskaayuningtyaswidyastani elusidasistrukturproduksampingdarihasilsintesissenyawathpgv1danujiantiinflamasisenyawathpgv1 AT drritmalenissi elusidasistrukturproduksampingdarihasilsintesissenyawathpgv1danujiantiinflamasisenyawathpgv1 |