| Summary: | Fracture is a problem that can cause damage to the bone cells and that bone
will lose its continuity. In the case of multiple fractures, delayed unions,
nonunions, and other bone diseases like osteosarcoma and chondrosarcoma,
a bone graft to replace and repair damaged bone are required.
The objective of this research was to compare demineralized freeze-dried
bovine bone xenograft (DFDBBX) and hydroxyapatite bovine bone xenograft
(HA-BBX) in fracture healing. Twenty four male Sprague Dawley rats, 6 weeks
of old were divided into 3 treated groups of 8 rats each. All groups were then
made of femur fractures in the middle part of femur bone. Group I (control) was
rats that operated and fixed with intramedullary pin without bone graft material,
Group II was rats that operated and fixed with both intramedullary pin and
DFDBBX, and Group III was rats that operated and fixed with both
intramedullary pin and HA-BBX.
The fracture healing process was evaluated based on radiologic and
histopathologic views. Blood analysis of total leucocytes and neutrophils were
analayzed statistically to see the inflammation reaction of the tissue that done in
the week of 2, 4, 6 and 8, whereas Radiologic and histopathologic views were
analyzed descriptively. Based on statistical analysis of total leucocytes and
neutrophils, it showed that inflammation process did not occur excessively in
fractured group treated with DFDBBX and HA-BBX as well (P>0.05). The result
of Radiologic and histopathologic analysis of fracture healing process in groups
treated with DFDBBX (II) and HA-BBX (III) showed a better progress if
compared to the Group I.
From all of the research results could be concluded that bovine bone grafts non
rejected reaction and save, beside that using HA-BBX more osteoinductive and
healing bone process has better than using DFDBBX.
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