| Summary: | One of the complications of panretinal laser photocoagulation patients for
diabetic retinopathy is macular edema. Increased of inflammatory mediators and
free radicals after panretinal laser photocoagulation was sugested play role in the
occurrence of macular edema. Curcumin has anti-inflammatory and anti-oxidant
actions. The objective of this study was to determine the effect of administration
of oral curcumin to prevent macular edema after panretina laser photocoagulation
in diabetic retinopathy patients.
A double blind randomized clinical trial study.. There were 35 subjects
with diabetic retinopathy consists of 58 eyes were included in this study. The
subjects then devided into two group by randomization. The curcumin group was
treated with capsulated Curcuma
®
200 mg powder 3 times 1 capsule daily for 4
weeks, while the control group was treated with placebo 3 times 1 capsule daily
for 4 weeks. Capsules began consumed after first session of panretinal laser
photocoagulation. Fast Macular Thicness scan methode with Stratus OCT
instrument used to assess the macular thickness just before and 4 weeks after
underwent panretinal after laser.
There was smaller increase in macular thickness which was clinically and
statisticaly significant found in the curcumin group compared to control who
underwent panretinal laser photocoagulation with or without grid laser (5,86 ±
28,01 vs 25,07 ± 36,43 µm
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