STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV) MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3
QSAR studies has been done on derivatives of triazolopiperazine amide as inhibitors DPP IV enzyme that causes diabetes mellitus type 2. The studies was begun by modeling the structures of the derivatives of triazolopiperazine amide and calcutating the descriptors of QSAR by semiempirical AM1 and...
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| Format: | Thesis |
| Published: |
[Yogyakarta] : Universitas Gadjah Mada
2013
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| _version_ | 1826046212698013696 |
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| author | Asmara, Anjar Purba Mudasir, Mudasir |
| author_facet | Asmara, Anjar Purba Mudasir, Mudasir |
| author_sort | Asmara, Anjar Purba |
| collection | UGM |
| description | QSAR studies has been done on derivatives of triazolopiperazine amide
as inhibitors DPP IV enzyme that causes diabetes mellitus type 2. The studies was
begun by modeling the structures of the derivatives of triazolopiperazine amide
and calcutating the descriptors of QSAR by semiempirical AM1 and PM3
methods which are available on Hyperchem� program. QSAR analysis was done
by multilinear regression method analysis which is available on SPSS� program
using electronic and molecular parameters. The best QSAR equation model for
method of semiempirical AM1:
-log -log IC50 = 155.259 + (13.149*qC1) + (1692.869*qC9) + (1300.431*qC10)
+ (601.809*qO25) + (4.762*EH)
n = 18 |
| first_indexed | 2024-03-13T22:49:39Z |
| format | Thesis |
| id | oai:generic.eprints.org:119421 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:49:39Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1194212018-05-25T06:54:32Z https://repository.ugm.ac.id/119421/ STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV) MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3 Asmara, Anjar Purba Mudasir, Mudasir Medical Biochemistry and Metabolomics QSAR studies has been done on derivatives of triazolopiperazine amide as inhibitors DPP IV enzyme that causes diabetes mellitus type 2. The studies was begun by modeling the structures of the derivatives of triazolopiperazine amide and calcutating the descriptors of QSAR by semiempirical AM1 and PM3 methods which are available on Hyperchem� program. QSAR analysis was done by multilinear regression method analysis which is available on SPSS� program using electronic and molecular parameters. The best QSAR equation model for method of semiempirical AM1: -log -log IC50 = 155.259 + (13.149*qC1) + (1692.869*qC9) + (1300.431*qC10) + (601.809*qO25) + (4.762*EH) n = 18 [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed Asmara, Anjar Purba and Mudasir, Mudasir (2013) STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV) MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3. Masters thesis, Universitas Gadjah Mada. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59422 |
| spellingShingle | Medical Biochemistry and Metabolomics Asmara, Anjar Purba Mudasir, Mudasir STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV) MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3 |
| title | STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA
SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV)
MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3 |
| title_full | STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA
SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV)
MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3 |
| title_fullStr | STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA
SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV)
MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3 |
| title_full_unstemmed | STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA
SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV)
MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3 |
| title_short | STUDI QSAR SENYAWA TURUNAN TRIAZOLOPIPERAZIN AMIDA
SEBAGAI INHIBITOR ENZIM DIPEPTIDIL PEPTIDASE-IV (DPP IV)
MENGGUNAKAN METODE SEMIEMPIRIK AM1 DAN PM3 |
| title_sort | studi qsar senyawa turunan triazolopiperazin amida sebagai inhibitor enzim dipeptidil peptidase iv dpp iv menggunakan metode semiempirik am1 dan pm3 |
| topic | Medical Biochemistry and Metabolomics |
| work_keys_str_mv | AT asmaraanjarpurba studiqsarsenyawaturunantriazolopiperazinamidasebagaiinhibitorenzimdipeptidilpeptidaseivdppivmenggunakanmetodesemiempirikam1danpm3 AT mudasirmudasir studiqsarsenyawaturunantriazolopiperazinamidasebagaiinhibitorenzimdipeptidilpeptidaseivdppivmenggunakanmetodesemiempirikam1danpm3 |