PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS PLASENTA ANTARA PREEKLAMPSIA BERAT DENGAN KEHAMILAN NORMOTENSI
Background: The placenta is a central focus and important in the pathogenesis of preeclampsia occurrence. Failure of trophoblast cells do remodeling spiral arteries due to excessive apoptosis causes uteroplacental ischemia and damage the endothelial cells that give rise to the clinical manifestation...
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| Format: | Thesis |
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[Yogyakarta] : Universitas Gadjah Mada
2013
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| author | , DEWA MADE SUCIPTA PUTRA , dr. Diah Rumekti Hadiati, M.Sc SpOG(K) |
| author_facet | , DEWA MADE SUCIPTA PUTRA , dr. Diah Rumekti Hadiati, M.Sc SpOG(K) |
| author_sort | , DEWA MADE SUCIPTA PUTRA |
| collection | UGM |
| description | Background: The placenta is a central focus and important in the pathogenesis of
preeclampsia occurrence. Failure of trophoblast cells do remodeling spiral arteries
due to excessive apoptosis causes uteroplacental ischemia and damage the
endothelial cells that give rise to the clinical manifestations of preeclampsia.
Excessive apoptosis in preeclampsia occurs through the intrinsic pathway of
apoptosis mediated intracellular where directly from mitochondria in response to
stress such as mitochondrial damage and can be activated by
p53, a protein that activates the tumor suppressive action of Bcl-2 proapoptotic.
Extrinsic and intrinsic pathways are not independent, because p53 can also
enhance the expression of several death receptors.
Objective: To compare the expression of p53 protein on pregnancy trophoblast
between severe preeclampsia complicated pregnancy and normotension
pregnancy.
Methods of study: This study is a cross-sectional design of the study population
of patients with severe preeclampsia 2011 to March 2012. Placental samples
obtained from 43 pregnancies with severe preeclampsia and 38 normotensive
placentas from pregnancies. Observation of P53 protein expression by
immunohistochemistry technique. Statistical analysis using independent t<0.05)..32 ± 0.18).
Results: There were significant differences (p = 0.00) p53 protein expression in
the gestational trophoblastic tissue severe preeclampsia (1.99 ± 0.66) compared to
the normotensive pregnancies (1
Conclusion: Expression of p53 protein in severe preeclampsia is higher than
normotensive pregnancies. |
| first_indexed | 2024-03-13T22:50:36Z |
| format | Thesis |
| id | oai:generic.eprints.org:119729 |
| institution | Universiti Gadjah Mada |
| last_indexed | 2024-03-13T22:50:36Z |
| publishDate | 2013 |
| publisher | [Yogyakarta] : Universitas Gadjah Mada |
| record_format | dspace |
| spelling | oai:generic.eprints.org:1197292016-03-04T08:30:01Z https://repository.ugm.ac.id/119729/ PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS PLASENTA ANTARA PREEKLAMPSIA BERAT DENGAN KEHAMILAN NORMOTENSI , DEWA MADE SUCIPTA PUTRA , dr. Diah Rumekti Hadiati, M.Sc SpOG(K) ETD Background: The placenta is a central focus and important in the pathogenesis of preeclampsia occurrence. Failure of trophoblast cells do remodeling spiral arteries due to excessive apoptosis causes uteroplacental ischemia and damage the endothelial cells that give rise to the clinical manifestations of preeclampsia. Excessive apoptosis in preeclampsia occurs through the intrinsic pathway of apoptosis mediated intracellular where directly from mitochondria in response to stress such as mitochondrial damage and can be activated by p53, a protein that activates the tumor suppressive action of Bcl-2 proapoptotic. Extrinsic and intrinsic pathways are not independent, because p53 can also enhance the expression of several death receptors. Objective: To compare the expression of p53 protein on pregnancy trophoblast between severe preeclampsia complicated pregnancy and normotension pregnancy. Methods of study: This study is a cross-sectional design of the study population of patients with severe preeclampsia 2011 to March 2012. Placental samples obtained from 43 pregnancies with severe preeclampsia and 38 normotensive placentas from pregnancies. Observation of P53 protein expression by immunohistochemistry technique. Statistical analysis using independent t<0.05)..32 ± 0.18). Results: There were significant differences (p = 0.00) p53 protein expression in the gestational trophoblastic tissue severe preeclampsia (1.99 ± 0.66) compared to the normotensive pregnancies (1 Conclusion: Expression of p53 protein in severe preeclampsia is higher than normotensive pregnancies. [Yogyakarta] : Universitas Gadjah Mada 2013 Thesis NonPeerReviewed , DEWA MADE SUCIPTA PUTRA and , dr. Diah Rumekti Hadiati, M.Sc SpOG(K) (2013) PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS PLASENTA ANTARA PREEKLAMPSIA BERAT DENGAN KEHAMILAN NORMOTENSI. UNSPECIFIED thesis, UNSPECIFIED. http://etd.ugm.ac.id/index.php?mod=penelitian_detail&sub=PenelitianDetail&act=view&typ=html&buku_id=59732 |
| spellingShingle | ETD , DEWA MADE SUCIPTA PUTRA , dr. Diah Rumekti Hadiati, M.Sc SpOG(K) PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS PLASENTA ANTARA PREEKLAMPSIA BERAT DENGAN KEHAMILAN NORMOTENSI |
| title | PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS
PLASENTA ANTARA PREEKLAMPSIA BERAT
DENGAN KEHAMILAN NORMOTENSI |
| title_full | PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS
PLASENTA ANTARA PREEKLAMPSIA BERAT
DENGAN KEHAMILAN NORMOTENSI |
| title_fullStr | PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS
PLASENTA ANTARA PREEKLAMPSIA BERAT
DENGAN KEHAMILAN NORMOTENSI |
| title_full_unstemmed | PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS
PLASENTA ANTARA PREEKLAMPSIA BERAT
DENGAN KEHAMILAN NORMOTENSI |
| title_short | PERBANDINGAN EKSPRESI PROTEIN p53 SEL TROPHOBLAS
PLASENTA ANTARA PREEKLAMPSIA BERAT
DENGAN KEHAMILAN NORMOTENSI |
| title_sort | perbandingan ekspresi protein p53 sel trophoblas plasenta antara preeklampsia berat dengan kehamilan normotensi |
| topic | ETD |
| work_keys_str_mv | AT dewamadesuciptaputra perbandinganekspresiproteinp53seltrophoblasplasentaantarapreeklampsiaberatdengankehamilannormotensi AT drdiahrumektihadiatimscspogk perbandinganekspresiproteinp53seltrophoblasplasentaantarapreeklampsiaberatdengankehamilannormotensi |