| Summary: | Background: Early detection of iron deficiency before anemia in early children
especially beyond 6-59 months become important due to its impact to permanent
neurocognitive development disorder. Bone marrow aspiration with Prussian blue
staining was not routinely done because of the invasive procedure. Hemoglobin is
unsensitive tool for iron deficiency without anemia and serum ferritin influenced
by infection and inflammation. Soluble transferrrin receptors (sTfR) is a sensitive
marker for detecting iron deficiency state but is not used widely in daily practice.
Objective: to determine the correlation between hemoglobin level, serum ferritin,
and soluble transferrin receptor in early children 6-59 months.
Methods: This cross sectional study was performed in 6-59 months old children
who visited POSYANDU in Yogyakarta and Bantul districs that choosen by
cluster sampling. Anamnesis, anthropometric and physical examination was
performed. Inclusion criteria were health children appropiate with anamnesis and
examination results. Children who received iron supplementation we excluded.
After fulfilled the informed consent, amount subjects are 85 children. After that,
blood sample was collected to examined hemoglobin, serum ferritin, and soluble
transferrin receptor level.
Results: Spearman correlation test showed a significant correlation between
hemoglobin level and serum ferritin level and also between hemoglobin level and
sTfR with coefficient correlation respectively r= -0,220 (p=0,043), r= -0,317
(p=0,003). Coefficient correlation between serum feritin level and sTfR was r=-
0,033 (p=0,767). Statistically, the correlation is not significant.
Conclusion: The increase level of hemoglobin will correlate with the decrease
level of serum ferritin and sTfR. Meanwhile, the increase level of serum ferritin
will correlate with the decrease level of sTfR.
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